Searchable abstracts of presentations at key conferences in endocrinology

ea0021oc4.4 | Bone and parathyroid | SFEBES2009

Rapid screening for novel bone phenotypes in 100 consecutive lines from the Wellcome Trust Sanger Institute Gene Targeting Programme

Gogakos Apostolos , Bassett Duncan , van der Spek Anne , Evans Holly , White Jacqui , Ramirez-Solis Ramiro , Steel Karen , Bradley Allan , Thakker Rajesh , Croucher Peter , Williams Graham

The Wellcome Trust Sanger Institute Gene Targeting Programme is deleting all mouse genes and has already generated 400 knockout mice in a C57/BL6N background with a further 4000 genes targeted in ES cells. Two hundred and fifty new knockouts will undergo limited phenotyping each year. However, the programme lacks a sensitive and sufficiently detailed screen for individual physiological systems, each of which requires high throughput methodology and unique expertise. Thus, we p...