Searchable abstracts of presentations at key conferences in endocrinology

ea0019p325 | Steroids | SFEBES2009

The effects of glucocorticoids on first trimester trophoblast

Mukherjee S , Cartwright J , Whitley G , Michael A , Thilaganathan B

Introduction: Glucocorticoids may exert important actions in early pregnancy on the invading trophoblast. The local actions of glucocorticoids can be modulated by 11β-hydroxysteroid dehydrogenase (11β-HSD) enzymes which catalyse inter-conversion of cortisol with its inert metabolite, cortisone. Although two cloned 11β-HSD isoenzymes are known to be expressed in the term placenta, their expression and activity have not been well characterised in the first trimest...

ea0007p176 | Reproduction | BES2004

The effects of thyroid hormone on cytokine-induced proliferation in human trophoblast cells

Barber K , Khanim F , McCabe C , Bulmer J , Whitley G , Franklyn J , Kilby M

Thyroid hormones are essential for optimum fetal neurodevelopment. In-utero nutrition is dependant on adequate placentation. Epidermal growth factor (EGF) and hepatocyte growth factor (HGF) have been demonstrated to affect proliferation of human trophoblast and may therefore play a role in adequate human placentation. Intrauterine growth restriction (a process associated with malplacentation) is associated with fetal hypothyroxinemia and enhanced thyroid receptor (TR) expressi...