Searchable abstracts of presentations at key conferences in endocrinology

ea0014p609 | (1) | ECE2007

Implications for molecular mechanisms of glycoprotein hormone receptors using a new sequence-structure-function analysis resource

Kleinau Gunnar , Brehm Mara , Wiedemann Urs , Labudde Dirk , Leser Ulf , Krause Gerd

Comparison between wild type and mutated glycoprotein hormone receptors (GPHRs) TSHR, FSHR and LHCGR is established to identify determinants involved in molecular activation mechanism. The basic aims of current work are the discrimination of receptor phenotypes according the differences between activity states they represent and hit-assignment of classified phenotypes to 3D-structural positions to reveal functional-structural hotspots and interrelations between determinants th...