Searchable abstracts of presentations at key conferences in endocrinology

ea0016p566 | Obesity | ECE2008

Prospective, Placebo controlled, randomized treatment of 67 obese children/adolescents with metformin

Wiegand Susanna , L'Allemand Dagmar , Huebel Hanna , Burmann Mareike , Krude Heiko , Gruters Annette , Holl Reinhard

Background: It becomes increasingly evident that features of the metabolic syndrome are already present in young obese patients. Especially an impaired glucose metabolism with insulin resistance is an alarming sign of existing comorbidity of childhood obesity. Metformin has been argued as one pharmacological option to improve impaired glucose metabolism at least in obese adults. So far three prospective randomized studies were performed in childhood cohorts with <30 patien...

ea0016p598 | Paediatric endocrinology | ECE2008

Aspects and features of type 2 diabetes and the metabolic syndrome in obese children and adolescents

Wiegand Susanna , Dannemann Almut , Galler Angela , Wessel Theda , Bickenbach Annika , Gruters Annette

Background: Obesity is a rising problem in developed and developing countries. Currently little is known about prevalence and prognosis of type 2 diabetes and the metabolic syndrome in obese children and adolescents in Europe.Patients and methods: About 491 obese children (mean-age 11.2 years; mean-BMI 30.3 kg/m2) were examined (lipid-profile; blood pressure, insulin-resistance1) and in 102 of them with risk factors for type 2 diabe...

ea0058oc4.1 | Oral Communications 4 | BSPED2018

Hydrocortisone granules in capsules for opening: phase 3 trial in children with adrenal insufficiency and long-term safety data

Lewis Alexander , Neumann Uta , Wiegand Susanna , Krude Heiko , Digweed Dina , Voet Bernard , Ross Richard , Davies Madhu , Blankenstein Oliver

Introduction: Children with adrenal insufficiency requiring hydrocortisone rely on compounded adult medication. This study aimed to evaluate the absorption, palatability and safety of Alkindi® (hydrocortisone granules in capsules for opening).Methods: The phase 3 study was an open-label, single-dose study in a total of 24 children (aged 0–6 years) with adrenal insufficiency. Fasted children were given a single dose of Alkindi&#1...

ea0020p472 | Obesity and Metabolism | ECE2009

Melanocortin-4-receptor gene variants: hotspot or identical by descent?

Grothe Jessica , Brumm Harald , Scherag Andre , Friedel Susann , Hinney Anke , Hebebrand Johannes , Illig Thomas , Grallert Harald , Wiegand Susanna , Krude Heiko , Farooqi Sadaf , Gruters Annette , Biebermann Heike

The melanocortin-4-receptor (MC4R) plays an important role in body weight regulation. Mutations in the MC4R gene are the most common genetic cause for obesity. The most frequent Northern European mutation is Y35X, associated with D37V on the same allele. Furthermore, there are two variants with a relatively high frequency: V103I and S127L. In rare cases, we identified the variants V103I and S127L on the same allele. The occurrence of two variants on the same allele makes a fou...

ea0016p555 | Obesity | ECE2008

Association study on three single nucleotide polymorphisms upstream and in the GIPR in obese and lean children from Berlin

Sauber Jeannine , Jyrch Sabine , Bronner Gunter , Friedel Susann , Illig Thomas , Grallert Harald , Hebebrand Johannes , Wiegand Susanna , Krude Heiko , Gruters Annette , Brumm Harald , Biebermann Heike

Introduction: In the past 20 years, obesity has become a major health problem occurring as well in adults as in children. Beside environmental influences on body weight, the genetic background of a person plays an important role in body weight control. After the description of monogenetic mutations linked to obesity most current studies investigate polygenetic forms of obesity.Recent studies showed an association between two SNPs, located in the promoter...

ea0016p556 | Obesity | ECE2008

Screening for mutations in the glucose-dependent insulinotrophic polypeptide receptor gene (GIPR) in obese patients with disturbed glucose tolerance

Behm Maria , Ambrugger Petra , Sauber Jeannine , Hinney Anke , Hebebrand Johannes , Friedel Susann , Bronner Gunter , Wiegand Susanna , Krude Heiko , Gruters Annette , Biebermann Heike

Objective: The increasing incidence of obesity is a major health problem world-wide. So far, mutations were identified in genes encoding major contributors in energy homeostasis. With the exception of mutations in the melanocortin-4-receptor gene (MC4R) obesity-causing mutations are very rare. To date great efforts were undertaken to identify gene variants that contribute to polygenic obesity. The GIPR belongs to the large superfamily of G-protein coupled recepto...

ea0014p203 | (1) | ECE2007

Decreased 11beta-hydroxysteroid dehydrogenase type 1 activity in obese boys

Wiegand Susanna , Richardt Anna , Remer Thomas , Wudy Stefan A , Tomlinson Jeremy W , Grüters Annette , Stewart Paul M , Strasburger Christian J , Quinkler Marcus

Objective: The incidence of childhood obesity and type 2 diabetes has reached epidemic proportions. Glucocorticoid excess causes central obesity and diabetes mellitus as seen in Cushing’s syndrome. The 11beta-hydroxysteroid dehydrogenase type 1 enzyme (11beta-HSD1), which is predominantly expressed in liver and adipose tissue, regenerates active cortisol from inactive cortisone. Increased 11beta-HSD1 may cause tissue-specific Cushing syndrome with central obesity and impa...

ea0013p193 | Diabetes, metabolism and cardiovascular | SFEBES2007

Reduced 11beta-hydroxysteroid dehydrogenase type 1 activity in obese children

Wiegand Susanna , Richardt Anna , Remer Thomas , Wudy Stefan A , Tomlinson Jeremy W , Hughes Beverly , Grüters Annette , Stewart Paul M , Strasburger Christian J , Quinkler Marcus

Objective: The incidence of childhood obesity and type 2 diabetes has reached epidemic proportions. Glucocorticoid excess causes central obesity and diabetes mellitus as seen in Cushing’s syndrome. The 11beta-hydroxysteroid dehydrogenase type 1 enzyme (11beta-HSD1), which is predominantly expressed in liver and adipose tissue, regenerates active cortisol from inactive cortisone. Altered 11beta-HSD1 may cause tissue-specific Cushing syndrome with central obesity and impair...