Searchable abstracts of presentations at key conferences in endocrinology

ea0016s6.2 | Insights in pancreatic development and new clinical aspects | ECE2008

The zinc-finger factor Insm1 (IA-1) is essential for the development of endocrine cells of the pancreas, intestine and adrenal gland

Birchmeier Carmen , Gierl Mathias , Wildner Hendrik , Wende Hagen

Endocrine cells of the intestine, pancreas and adrenal gland develop from the endoderm and neural crest, respectively. Despite their different developmental origins, we discovered that these distinct endocrine cells rely on a common transcription factor, Insm1, that controls their development. The Insm1 (insulinoma-associated 1, IA-1) gene encodes a zinc-finger factor that was discovered in an insulinoma cDNA library. We show that pancreatic and intestinal endocrine cells as w...