Searchable abstracts of presentations at key conferences in endocrinology

ea0039oc7.5 | Oral Communications 7 | BSPED2015

Investigating the impact of post-translational modification of Type 1 diabetes auto-antigens by tissue transglutaminase.

Donnelly Catherine , Williams Alistair

Background: Post-translational modification (PTM) of antigens has been shown to play a role in the pathogenesis of autoimmune disorders. In coeliac disease (CD), tissue transglutaminase (tTG) deamidates gliadin peptides to activate the immune response against gut endomysium. CD is six times more prevalent in Type 1 diabetes (T1D) patients than in the general population.Hypothesis: tTG also modifies auto-antigens implicated in the pathogenesis of T1D, lea...