Searchable abstracts of presentations at key conferences in endocrinology

ea0077oc3.4 | Metabolism, Obesity and Diabetes | SFEBES2021

Hepatic choline deficiency underpins amelioration of visceral obesity and diabetes in ectonucleotide pyrophosphatase (Enpp)-6–/– mice

Wang Rongling , Schraut Katharina , Carter Roderick , Kentistou Katherine , Wilson James , Michailidou Zoi , Webster Scott , Morton Nicholas

The global prevalence of obesity continues to rise, creating a growing need for new effective medicines. Selective targeting of visceral obesity (fat around the internal organs) would be particularly advantageous because it carries a greater risk for cardiometabolic diseases. The ectonucleotide pyrophosphatase (ENPP) enzyme family participates in several pathological conditions including diabetes (ENPP1, and ENPP2, also known as autotaxin) and vascular dysfunction (ENPP3-4). O...

ea0034p241 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2014

Diabetes in pregnancy and birth weight: differential effects due to ethnicity in a real-life observational study

Wilson James , Venkataraman Hema , Cheong Jessica , Sukumar Nithya , Khunti Kamlesh , Saravanan Ponnusamy

Background: Macrosomia (BW >4.5 kg) is a well-recognised complication of maternal hyperglycaemia and is associated with poor maternal and foetal outcomes. Traditional risk factors of macrosomia do not fully explain all variation as it can happen in normoglycaemia and in well-controlled diabetes. The relative contributions of these factors in different ethnicities are unknown. We investigated the predictors of BW in South Asian (SA) and White Caucasian (WC) pregnancies, and...