Searchable abstracts of presentations at key conferences in endocrinology

ea0081rc8.1 | Rapid Communications 8: Calcium and Bone | ECE2022

Growth hormone excess in fibrous dysplasia and mccune albright syndrome (FDMAS)

Dănilă Oana O , Geels Raya ES , Claessen Kim , Meier Maartje E , Winter Elizabeth M , Biermasz Nienke , Appelman-Dijkstra Natasha M

Introduction: Fibrous dysplasia (FD)/McCune Albright Syndrome (MAS) is a rare disorder affecting bone and hormonal glands. In FDMAS patients, autonomous GH hypersecretion (GH+) is the most common endocrinopathy after Precocious Puberty and has a great impact on the morbidity and complication rate in patients with craniofacial fibrous dysplasia. However clinical and biochemical features of GH over secretion can be subtle and awareness is warranted. We aimed to explore the GH/IG...

ea0070oc2.4 | Bone and Calcium | ECE2020

Loss of glucocorticoid rhythm induces an osteoporotic phenotype in mice

Winter Elizabeth M , Schilperoort M , Kroon J , Kooijman S , Mletzko K , Busse B , Pereira AM , Appelman-Dijkstra NM , Bravenboer N , Rensen PCN , Meijer OC

Introduction: Glucocorticoid (GC)-induced osteoporosis is a widespread problem that is accompanied with increased fracture risk. Currently, it is unknown whether detrimental effects of GC therapy on bone are simply the consequence of supraphysiological GC doses, or whether absence of the endogenous GC rhythm also plays a role. In this study, we aimed to elucidate the importance of the presence of a diurnal corticosterone (CORT) rhythm, the primary GC in mice, for bone quality....

ea0073oc6.3 | Oral Communications 6: Calcium and Bone | ECE2021

Bone material strength index is altered in patients with Cushing’s syndrome even after long-term remission

Schoeb Manuela , Sintenie Paula J.C. , Haalen Femke van , Nijhoff Michiel , de Vries Friso , Biermasz Nienke , Winter Elizabeth M. , Pereira Alberto M , Appelman-Dijkstra Natasha

BackgroundEndogenous CushingÂ’s syndrome (CS) is detrimental to bone. The skeletal complications are characterized by decreased bone formation and increased bone resorption, resulting in decreased bone mineral density (BMD) and an increased risk of fractures at time of diagnosis. After remission of the disease, BMD improves towards normal values but fracture rate remains elevated. Therefore, components of bone quality other than BMD, such as bone mat...