Searchable abstracts of presentations at key conferences in endocrinology

ea0022p742 | Steroid metabolism & action | ECE2010

Tissue expression of the CYP19A1 gene and aromatase protein in male cynomolgus monkeys (Macaca fascicularis)

Pignatti Elisa , Lachhab Asmaa , Casarini Livio , Wistuba Joachim , Schlatt Stefan , Carani Cesare , Simoni Manuela

Objective: Aromatase, the key enzyme involved in estrogen synthesis, is expressed in a variety of cells, including peripheral blood leukocytes (PBLs), and tissues. The systematic study of aromatase expression and activity in different tissues in the human and other primates, however, is difficult and still missing. Although is not really known, aromatase expression in PBLs could be used as parameter of aromatase expression/activity making PBLs a potential alternative for other...

ea0016oc5.9 | Reproduction | ECE2008

Cognitive disabilities in the novel object task of male mice carrying a supernumerary X chromosome (41, XX*Y)

Wistuba Joachim , Damm Oliver , Luetjens C Marc , Simoni Manuela , Nieschlag Eberhard , Lewejohann Lars

Introduction: Several numerical chromosome abberations are known in men. Of those the karyotype XXY (Klinefelter syndrome KS) is the most common chromosomal disorder with a prevalence of about one in 500 live-born males. KS is associated with hypogonadism and is suspected to cause variable physical and cognitive abnormalities. As a supernumerary X chromosome is also associated with infertility, sound animal models for KS are difficult to obtain.Methods: ...

ea0041ep711 | Male Reproduction | ECE2016

Altered testicular vascularization and impaired blood supply in the 41,XXY* mouse model for Klinefelter syndrome

Brand Cristin , Damm Oliver S , Warmeling Ann-Sophie , Sandhowe-Klaverkamp Reinhild , Werler Steffi , Koerner Katharina , Stypmann Joerg , Kuhlmann Michael , Holtmeier Richard , Zitzmann Michael , Tuettelmann Frank , Gromoll Joerg , Wistuba Joachim

Intratesticular testosterone levels in Klinefelter syndrome (KS) are comparable to controls and Leydig cell function was proven to be normal at least in vitro, testicular vascularization changes came into focus as a potential factor contributing to hypogonadism. We performed enhanced ultrasound based analysis of the testicular blood support in our 41,XXY* mice. Adult male 41,XXY* (n=5) and control mice (n=6) underwent ultrasound...