Searchable abstracts of presentations at key conferences in endocrinology

ea0014p139 | (1) | ECE2007

Survivin – a promising target for immunotherapy in patients with adrenocortical carcinoma

Fassnacht Martin , Wortmann Sebastian , Sbiera Silviu , Kuehner Dorothee , Wobser Marion , Adam Patrick , Becker Juergen C. , Allolio Bruno

Objectives: Adrenocortical carcinoma (ACC) is a rare tumor with poor prognosis and limited therapeutic options. Survivin is an anti-apoptotic molecule expressed by neoplastic and tumor-specific endothelial cells of various carcinomas, but rarely or only weakly in normal differentiated tissue. In melanoma and pancreatic cancer, preliminary results of a survivin vaccination trial ( indicated that an immunological response in patients is often paralleled by...