Searchable abstracts of presentations at key conferences in endocrinology

ea0014p17 | (1) | ECE2007

Does stress test influence Interleukin (IL)-2 and IL-8 concentration in serum patients with stable ischaemic heart disease?

Romanowski Wojciech , Szkodzinski Janusz , Kaszuba Andrzej , Blazelonis Adam , Muryn Zuzanna , Anna Pietka-Rzycka , Zubelewicz-Szkodzinska Barbara

Background: There is growing evidence that adhesion molecules, proinflammatory cells and cytokines play an important role in a variety of cardiac pathophysiological conditions; Cytokines are responsible for the modulation of immune and inflammatory processes. It has been suggested that cytokines such as IL-1, IL-2, IL-6, IL-10 and TNF alpha are important modulators of atherosclerotic effects with IL-2 and Interferon γ having a proinflammatory atherogenic effect and IL-8 a...

ea0014p18 | (1) | ECE2007

Concentration of inflammatory factors such as CRP (acute phase response protein) and Interleukin (IL)-6 in serum patients with stable ischemic heart disease during trimetazidine treatment

Szkodzinski Janusz , Szewczyk Marek , Romanowski Wojciech , Danikiewicz Aleksander , Muc-Wierzgon Malgorzata , Zubelewicz-Szkodzinska Barbara

Background: The patomechanism of developing ischemic heart disease (i.h.d.) is stenosis of coronary blood vessels with plaque placed on vascular endothelium built with monocytes/macrophages, foam cells, oxidized LDL, leukocytes, platelets and collagen. Atherosclerotic lesions are heavily infiltrated by cellular components associated with inflammation and influenced by other inflammatory factors. Trimetazidine, a clinically effective antianginal agent acts by optimizing cardiac...

ea0014p16 | (1) | ECE2007

Changes in growth hormone messenger RNA (GHmRNA) expression in rats anterior pituitary after single Interferon (IFN)alpha administration.

Romanowski Wojciech , Braczkowski Ryszard , Danikiewicz Aleksander , Nowakowska-Zajdel Ewa , Muc-Wierzgon Malgorzata , Muryn Zuzanna , Zubelewicz-Szkodzinska Barbara

Introduction: Interferon alpha (IFN alpha) is a cytokine with pleiotropic effects and via different pathways influences secretion of certain cytokines and hormones. Growth Hormone (GH) secreted from the pituitary has its physiological effects on various target tissues. The question is how IFN alpha administered in various type of diseases influences GH secretion. This study investigated acute effect of IFN-alpha on GH mRNA expression in rat anterior pituitary<p class="abst...