Searchable abstracts of presentations at key conferences in endocrinology

ea0063mtbs2 | (1) | ECE2019

Genetically tailored pig models in translational endocrine and metabolic research

Wolf Eckhard

The pig is an interesting model species for translational endocrine and metabolic research. Many organ systems relevant for endocrine research, including pancreas and gastrointestinal tract, are more similar to the corresponding human organs than those of other species. The human-like size and weight of pigs allows direct transfer of medical products, surgical techniques and in vivo imaging techniques to applications in human patients. Moreover, metabolic tests, such ...

ea0041oc6.4 | Diabetes therapy & complications | ECE2016

LEA29Y expression in transgenic porcine islets prevents islet graft rejection in humanized mice without systemic immunosuppressive therapy

Wolf-van Buerck Lelia , Schuster Marion , Baehr Andrea , Klymiuk Nik , Wolf Eckhard , Seissler Jochen

Transplantation of pancreas or isolated Langerhans islets can cure type 1 diabetes. Xenografts from transgenic pigs represent a promising source to overcome the shortage of organ donors. We investigated the immunosuppressive effect of local LEA29Y expression (a high-affinity variant of CTLA4-Ig) by transplantation of neonatal porcine islet-like clusters (NPICCs) from INSLEA29Y transgenic pigs into humanized mice. NPICCs from 1–5 day-old pigs expressing LEA29Y und...

ea0014oc11.4 | Reproductive endocrinology II | ECE2007

EGFR ligands mediate key events of female reproduction: reduced litter size due to impaired fertilization in a transgenic mouse model

Schneider Marlon R. , Gratao Ana A. , Dahlhoff Maik , Sinowatz Fred , Wolf Eckhard

EGFR ligands, a family of seven related peptide growth factors, are emerging as key factors regulating different aspects of female reproduction including oocyte maturation and ovulation, and implantation. Betacellulin (BTC) is a rather neglected EGFR ligand whose biological activities have been mostly associated with the endocrine pancreas. During the routine breeding of recently established BTC transgenic mouse lines (Schneider et al., Endocrinology 146, 5237–5246, 2005)...

ea0014p21 | (1) | ECE2007

Improved glucose metabolism and altered pancreatic structure in transgenic mice overexpressing betacellulin

Dahlhoff Maik , Herbach Nadja , Wanke Rüdiger , Wolf Eckhard , Schneider Marlon R.

Betacellulin, one of several peptides activating the EGFR (ErbB1) and related receptors, is a multipotent growth factor known to posses the unique ability to promote growth and differentiation of pancreatic β-cells.We investigated the effects of betacellulin overexpression in a recently established transgenic mouse model (Schneider et al., Endocrinology 146, 5237–5246, 2005). In transgenic animals, overall glucose metabolism was improved...