Searchable abstracts of presentations at key conferences in endocrinology

ea0012oc24 | Pituitary, ovary and steroids | SFE2006

Influence of C-type natriuretic peptide (CNP) on cell proliferation in αT3-1 gonadotrophs and GH3 somatotrophs

Thompson IR , Jonas KC , Wolf S , Lawson C , Wheeler-Jones CP , Fowkes RC

C-type natriuretic peptide (CNP) acts via its specific membrane-bound guanylyl cyclase receptor, GC-B, to stimulate cGMP production. Stimulation of cGMP impinges upon PKG and PKA signalling, leading to cell proliferation and cell cycle events. In endothelial cells, CNP is thought to perform a predominantly anti-mitogenic role, but the role of CNP on cell proliferation, cell cycle and DNA synthesis in pituitary cell lines has yet to be established. Using the mouse gonadotroph-d...