Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep383 | Diabetes (pathiophysiology & epitemiology) | ECE2015

Mechanisms of development of carbohydrate metabolism disturbances in acromegalic patients depending on treatment

Dreval Alexander V , Trigolosova Irina V , Vinogradova Anna V , Wolffenbuttel Bruce H R

Background: In acromegaly, carbohydrate metabolism disorders (CMD) are frequently observed. The effect of therapy of acromegaly on pathogenesis of CMD is not clear.Aim: To assess the effect of somatostatin analogues (SSA) on pathogenesis of carbohydrate metabolism disturbance in acromegaly.Patients and methods: 103 acromegaly patients were examined (31 men, 72 women; age 54 (46–61) years; 60 had newly diagnosed acromegaly (NA)...

ea0035p373 | Diabetes (epidemiology, pathophysiology) | ECE2014

Acromegaly treatment and carbohydrate metabolism disturbances

Dreval Alexander V. , Trigolosova Irina V. , Vinogradova Anna V. , Ilovayskaya Irena A. , Wolffenbuttel Bruce H.R.

Background: In acromegaly, carbohydrate metabolism disorders (CMD) are frequently observed. We aimed to assess the differences in insulin secretion and sensitivity depending on stage of the disease and type of treatment.Design: Sixty-four patients with acromegaly (46 women; age 53 (interquartile range, IQR 47–59) years), of whom 29 were newly-diagnosed (NA group), 20 treated with somatostatin analogues (SSA group) and 15 after transsphenoïdal s...

ea0016p803 | Thyroid | ECE2008

Thyroid peroxidase antibodies and levels of thyroid stimulating hormone as predictors of development of hypothyroidism in euthyroid subjects

Roos Annemieke , Links Thera , Jong-van den Berg Lolkje de , Gans Rijk , Wolffenbuttel Bruce , Bakker Stephan

Introduction: Presence of thyroid peroxidase antibodies (TPOAbs) may be a marker of future thyroid failure. However, prospective studies in a euthyroid population have not been performed.Aim of the study: To prospectively investigate the relationship between presence and levels of TPOAbs and incident hypothyroidism in euthyroid subjects in the general population.Study population: The database used for this study consisted of a rand...

ea0049oc9.1 | Thyroid Disease 2 | ECE2017

Thyroid function and metabolic syndrome: results from the population-based LifeLines Cohort study

Wolffenbuttel Bruce , Wouters Hanneke , Slagter Sandra , van Waateringe Robert , van Vliet-Ostaptchouk Jana , Links Thera , van der Klauw Melanie

Background: The metabolic syndrome (MetS) is a combination of unfavourable health factors including abdominal obesity, dyslipidaemia, hypertension and impaired fasting glucose. Several small-scale studies have reported a relationship between thyroid function and some MetS components or suggested that serum FT3 levels within the normal range were independently associated with insulin resistance. We assessed how thyroid function relates to the prevalence of MetS in a large popul...

ea0049ep672 | Obesity | ECE2017

Unfavourable blood pressure and lipid levels in obese individuals from the general population

Wolffenbuttel Bruce , Slagter Sandra , van Waateringe Robert , van Vliet-Ostaptchouk Jana , van Beek Andre , van der Klauw Melanie

Background: Early diagnosis and treatment of high blood pressure (BP) and high cholesterol is important to reduce cardiovascular mortality risk.Methods: We assessed actual BP and LDL-cholesterol (LDL-C) levels in 88,029 participants (36,122 men), aged 18-80 yrs, without diabetes, from the Dutch Lifelines Cohort study. Participants were categorized according to degree of obesity (normal weight, overweight, obese) and age decade group. BP measurement was r...

ea0041gp71 | Diabetes | ECE2016

A critical evaluation of the metabolic syndrome definition: why we should be more cautious

Slagter Sandra , van Waateringe Robert , van Beek Andre , van der Klauw Melanie , van Vliet-Ostaptchouk Jana , Wolffenbuttel Bruce

Aim: We assessed in both men and women within different BMI- and age classes the prevalence of MetS and its individual components, since these specific estimates obtained simultaneously in a large western European population are lacking. Secondly, we measured as well how age-specific blood pressure (BP) cut-offs affect the prevalence of elevated BP and MetS.Methods: Data of 74 531 western European participants, aged 18–79 years, were obtained from t...

ea0041ep403 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Prevalence of diabetes mellitus in patients with hypercortisolism

Dreval Alexander , Trigolosova Irina , Kruglyakova Margarita , Komerdus Irina , Misnikova Inna , Kovaleva Yulia , Chekanova Anastasia , Barsukov Ilya , Molchanova Galina , Wolffenbuttel Bruce

Background: Early carbohydrate metabolism disorders (ECMDs) and diabetes mellitus (DM) are frequently associated with endogenous hypercortisolism (EG). Prevalence of secondary (sDM) in these cases are poorly investigated.Aim: We aimed to assess the prevalence of ECMDs and DM in patients with EG (pituitary-dependent Cushing disease (CD)) and adrenal-dependent Cushing (AC) and ACTH-ectopic syndrome (ACTHs) depending on gender and age.<p class="abstext"...

ea0035p760 | Obesity | ECE2014

Worsening of cardiovascular risk with increasing number of components of metabolic syndrome in obese non-diabetic individuals

Wolffenbuttel Bruce , Slagter Sandra , Beek Andre Van , Lutgers Helen , Vliet-Ostaptchouk Jana Van , Klauw Melanie Van der

Introduction: The metabolic syndrome (MetS) is a strong predictor of cardiovascular risk. It is influenced by environmental factors, and its prevalence is high in subjects with obesity.Design: We assessed differences in glucose- and lipid parameters, and hsCRP and microalbuminuria (MA) in obese subjects with and without metabolic syndrome (MetS) in LifeLines, a population-based study. Included were subjects 18–80 years, with BMI>30 kg/m2</s...

ea0035p761 | Obesity | ECE2014

Health-related quality of life relates to obesity and low-grade inflammation in obese individuals

Slagter Sandra , Wolffenbuttel Bruce , Beek Andre Van , Lutgers Helen , Vliet-Ostaptchouk Jana Van , Klauw Melanie Van der

Introduction: Obesity is increasingly prevalent in Western society. In addition to medical consequences, obesity also affects health-related quality of life (HR-QOL).Design: We assessed the differences in HR-QOL in obese participants with and without metabolic syndrome (MetS), by level of obesity and level of inflammation, in the LifeLines Cohort study, a population-based study. In total, 12 765 subjects age 18–80 years, with BMI >30 kg/m2<...

ea0032p751 | Obesity | ECE2013

Associations between smoking and components of the metabolic syndrome

Slagter Sandra , van Vliet-Ostaptchouk Jana , Vonk Judith , Boezen Marike , van Beek Andre , van der Klauw, Bruce Wolffenbuttel Melanie

Background: The clustering of metabolic and cardiovascular risk factors is known as the metabolic syndrome (MetS). Lifestyle factors like smoking may contribute to the differences in prevalence of the MetS. The aim of this study was to examine the association between smoking and the MetS and its components in different BMI classes.Methods: The present cross-sectional evaluation comprised 24 762 men and 35 558 women, participating in the LifeLines Cohort ...