Searchable abstracts of presentations at key conferences in endocrinology

ea0003oc30 | Metabolism | BES2002

Increased muscle oxidation of dietary lipid contributes to oestrogen-induced improvements in postprandial lipid metabolism

Masding M , Stears A , Gelauf C , Burdge G , Wootton S , Sandeman D

Aims: Endogenous and exogenous oestrogens have previously been shown to improve postprandial lipid metabolism, probably due to up-regulation of hepatic LDL receptors. We used stable isotope techniques to investigate the contribution of muscle oxidation of dietary lipid to this improvement.Methods: Matched groups of healthy premenopausal (n=8) and postmenopausal (n=8) women and postmenopausal women taking oestrogen replacement therapy (HRT;...

ea0025p146 | Diabetes, metabolism and cardiovascular | SFEBES2011

Postprandial hypertriglyceridaemia in patients with polycystic ovary syndrome

Aye Myint M , Afolabi Paul R , Sathyapalan T , Wakil Ammar , Wootton S A , Sandeman Derek D , Kilpatrick Eric S , Atkin Stephen L

Background: Postprandial hypertriglyceridaemia is an independent risk factor for cardiovascular diseases. An acute rise of insulin in the fed state suppresses hormone-sensitive lipase to inhibit free fatty acids (FFAs) mobilisation from adipose tissue, and up-regulates lipoprotein lipase to increase FFAs influx to adipose tissue from chylomicrons, that is blunted in insulin resistant states. Polycystic ovary syndrome (PCOS) is associated with insulin resistance and cardiovascu...