Searchable abstracts of presentations at key conferences in endocrinology

ea0059cmw5.1 | Workshop 5: How do I. . . (2) | SFEBES2018

How do I manage endocrinopathies in HIV patients?

Wren Alison

Endocrinopathy is common in patients with HIV and presents a distinct series of challenges. Polypharmacy is common (both of prescribed and non-prescribed drugs) with the potential for drug-drug interactions and endocrine adverse effects of longterm medication. Structural pathology is also commoner than in the general population with the potential for both tumours and atypical infections affecting endocrine organs. Altered binding proteins are common, particularly high SHBG, af...

ea0028cmw4.2 | How do I approach... | SFEBES2012

Endocrine assessment in HIV/AIDS

Wren Alison

The true prevalence of clinically significant endocrine disease in HIV is difficult to get a handle on as the literature is in many cases Declaration of interesting or insufficiently illuminating. There is clearly potential for endocrine dysfunction, via many mechanisms including directly due to HIV, due to atypical infections and the drugs used to treat them, side effects of both prescribed and non-prescribed medications and structural pathology. Probably the best described e...

ea0015p361 | Thyroid | SFEBES2008

Carbimazole induced agranulocytosis: an unusual manifestation

Zalin Ben , Wren Alison

We present here the case of a 33-year-old woman, previously fit and well who presented initially with thyrotoxic symptoms. TFTs showed TSH <0.05, fT3 40. Thyroid uptake scan showed homogenous uptake of 8%. She was prescribed carbimazole 40 mg od and propanolol 40 mg bd with improvement.One month later, she presented to A+E with abdominal pain associated with diarrhoea and vomiting. She was found to be unwell, tachycardic and febrile. She had a global...

ea0018p10 | (1) | MES2008

Positive correlation between radioisotope and CT/MRI imaging techniques in functioning adrenal adenomas may obviate the need for invasive adrenal vein sampling

Fountain Annabel , Vaks Vladimir , Wren Alison

A 48-year-old Afro-Caribbean female was referred from Accident & Emergency in December 2007 with low serum potassium. She had been diagnosed elsewhere with hypertension due to primary aldosteronism at the age of 28 but was then lost to Endocrine follow-up. She reported intolerance to spironolactone – blood pressure was controlled with Amiloride until 1999 and then Amlodipine. Questioning in clinic, January 2008, revealed that she had had extensive investigations when ...

ea0055p31 | Poster Presentations | SFEEU2018

Hyperprolactinaemia, Cushing’s syndrome and Adrenal Insufficiency - diagnostic and management challenges with multiple co-morbidities and polypharmacy

Quinn Patrick , Siddiqui Mohsin , Morganstein Daniel , Wren Alison

Case history: A 51 year old lady was referred to Endocrinology with low plasma cortisol, hyperprolactinaemia and galactorrhoea. Extensive past medical history included primary hypothyroidism, B12 deficiency, diaphragmatic paralysis requiring NIV, recurrent aspergillomas, sino-atrial node disease with PPM, immunodeficiency, inflammatory arthropathy and autoimmune pancreatic insufficiency. She took numerous medications:- Itraconazole 100 mg daily, Levothyroxine 75 μg daily,...

ea0062p47 | Poster Presentations | EU2019

Two cases of ectopic ACTH in advanced NETs

Priest Josephine , Kok Kimberly , Wren Alison , Watkins David , Morganstein Daniel

Case history: Patient 1, a 78 year old male, was diagnosed five years ago with a metastatic NET with octreotide avid disease including ileocolic/right common iliac nodal metastases and a solitary segment VII liver lesion. He elected for watchful waiting and was asymptomatic. Interval imaging showed gradual local disease progression. He was diagnosed with motor neurone disease resulting in unilateral arm weakness. He re-presented four years after diagnosis with progressive weak...

ea0062p64 | Poster Presentations | EU2019

5-year survival in poor prognosis adrenocortical carcinoma without mitotane treatment

Kok Kimberly , Gertrude Priest Josephine , Morganstein Daniel , Wren Alison

Case history: 52 year old gentleman presented in 2013 with a 1 year history of abdominal pain. Imaging to screen for gallstones identified a large adrenal mass which was radiologically suspicious for adrenal carcinoma with probable inferior vena cava (IVC) involvement.Investigations: Overnight dexamethasone suppression test (ONDST) failed to suppress cortisol (324 nmol/l) with undetectable ACTH (<5 ng/l). Failure of suppression on low dose dexamethas...

ea0019p25 | Clinical practice/governance and case reports | SFEBES2009

Prevalence and identification of vitamin D deficiency in a falls population

Gunn Harriet M , Bovill Inaki , Wren Alison M

Background: Falls in the elderly are a major public health burden as more than one in three people over 65 years falls per annum. Vitamin D deficiency is common in the elderly due to decreased sunlight exposure, dietary vitamin D intake and efficiency of cutaneous vitamin D production. Vitamin D deficiency causes myopathy, impaired psychomotor function and increased sway thus increasing the risk of falls, whilst supplementation decreases falls. We hypothesized that vitamin D d...

ea0015oc15 | Reproduction | SFEBES2008

Evaluation of the prevalence of vitamin D deficiency and its treatment in a West London pregnant population

Salmasi Huda , Banerjee Anita , Donaldson Mandy , Wren Alison M

Vitamin D deficiency is a particular concern in pregnancy as it can affect both mother and infant, with problems lasting into childhood. A high prevalence of deficiency during pregnancy has been reported among known risk groups. Current guidelines on supplementing pregnant women are conflicting, with universal replacement recommended by the Department of Health but not supported by NICE guidelines. We aimed to determine the prevalence of vitamin D deficiency in a West London p...

ea0050p057 | Bone and Calcium | SFEBES2017

Imaging in primary hyperparathyroidism; does it affect our referral pathways for surgery? Results of an audit

Dede Anastasia , Morganstein Daniel , Shotliff Kevin , Greener Veronica , Smellie James , Maenhout Annelies , Wren Alison

Introduction: The 4th International Workshop on asymptomatic primary hyperparathyroidism (PHPT) has set criteria for surgical intervention and suggests that a percentage of patients can be managed conservatively. Imaging is indicated only pre-operatively to determine the optimal surgical approach.Patients and methods: We completed an audit on the use of Sestamibi, clinical and biochemical data in patients with PHPT.<...