Searchable abstracts of presentations at key conferences in endocrinology

ea0035s8.3 | Membrane lipid composition and receptor function. Signalling and trafficking | ECE2014

Membrane dynamics in physiology and disease: PI3K signaling

Wymann M

Phosphoinositide 3-kinase γ (PI3Kγ) is key to inflammation, allergy, cardiovascular, and metabolic disease.1 PI3Kγ is a drug target in chronic inflammation, rheumatoid arthritis,2 atherosclerosis3 and allergic responses.4,5 Localized, PI3Kγ-mediated PtdIns (3,4,5)P3 production5, and a distinct role of Ras selectively activating the p84–PI3Kγ-complex, can modulate PI3Kγ...