Endocrine Abstracts

Introduction: Hyperthyroidism is a common endocrine disorder in pregnancy, with potentially significant foeto-maternal consequences.Description of the case: 25 year old lady with auto-immune hyperthyroidism (TRAb>400) was treated with Propranolol and Carbimazole and referred to the Endocrine clinic. She was started on Block and replace therapy. She was soon moved over to Carbimazole as she was contemplating pregnancy. She became hypothyroid in 3 mont...

A 26-year-old Caucasian female presented at 14 weeks gestation with a 6-week history of lethargy, nausea and vomiting during her first pregnancy. Her adjusted Calcium was 4.12 mmol/l and parathyroid hormone (PTH) 26 pmol/l, consistent with possible primary hyperparathyroidism. She was previously well apart from occasional migraines. There was no known history of familial hypercalcaemia or MEN. Other biochemistry results revealed hypokalaemia of 3.2 mmol/l, low vitamin D at 16 ...

A 26-year-old primigravida woman presented with hypercalcaemia at 8-weeks gestation. Initial symptoms included nausea, vomiting and palpitations, with an admission serum adjusted calcium of 3.8 mmol/l. A biochemical diagnosis of primary hyperparathyroidism (PHPT) was supported by a raised PTH and a 24-hour urinary calcium-creatinine ratio of 2.0 mmol/ mmol, excluding familial hypocalciuric hypercalcaemia. Initial management with intravenous fluids and antiemetics was unable to...