Searchable abstracts of presentations at key conferences in endocrinology

ea0020p362 | Diabetes and Cardiovascular | ECE2009

Klotho gene polymorphism may be a genetic risk factor for metabolic syndrome in men

Katsoulis Constantinos , Chatzikyriakidou Anthi , Xita Nektaria , Georgiou Ioannis , Tsatsoulis Agathocles

Introduction: Klotho has an important role in insulin signaling and the development of ageing-like phenotypes in mice. Recently, the G-395A polymorphism in the promoter region of the human klotho gene has been reported to affect promoter function. It has been also shown to be an independent genetic risk factor for atherosclerotic cardiovascular disease. The aim of this study was to examine the possible role of this polymorphism in the metabolic syndrome....

ea0014p263 | (1) | ECE2007

The importance of (TAAAA)n polymorphism of SHBG gene in the metabolic syndrome

Xita Nektaria , Milionis Charalambos , Georgiou Ioannis , Elisaf Moses , Tsatsoulis Agathocles

Introduction: Sex hormone binding globulin (SHBG) levels have been associated with the development of the metabolic syndrome. In particular, low SHBG levels have been proposed as an indicator of increased risk for metabolic syndrome in men. The (TAAAA)n repeat polymorphism SHBG gene is believed to affect SHBG levels. In vitro experiments have shown that the allele with 6 TAAAA repeats is associated with decreased transcriptional activity of SHBG gene. The aim of this study was...

ea0014p207 | (1) | ECE2007

Association of estrogen receptor-alpha gene polymorphisms with cerebrovascular disease in patients with metabolic syndrome

Xita Nektaria , Markoula Sophia , Lazaros Leandros , Kyritsis Athanasios , Georgiou Ioannis , Tsatsoulis Agathocles

Introduction: The vascular protective effects of estrogens are known to be mediated by their binding to specific estrogen receptors (ER). However, the significance of genetic variations of the ER in vascular diseases has not been reported. We have examined the association between stroke and PvuII and XbaI polymorphisms of the estrogen receptor-alpha gene in patients with metabolic syndrome.Methods and subjects: The study population consisted by 84 male a...