Endocrine Abstracts

Introduction: Calcium transport is regulated by active transcellular and passive paracellular pathways which are responsible for calcium (re)absorption in the intestine and kidney. The activity of passive transport is determined by the permeability of tight junction. In general, the permeability of tight junction is inversely proportional with the expression of tight junction genes. Claudin and occludin among the tight junction genes are concerned directly with permeability of...

Background: Premature ovarian failure (POF) is a complex disorder defined as the cessation of ovarian function before or at the age of 40. Although the etiology of POF remains unknown in a large proportion of cases, it has been suggested that variations in the Inhibin α gene (INHA) may affect the ovarian function of women. This study was performed to investigate whether the genetic polymorphisms of the INHA gene are associated with idiopathic POF in a Korean population.</...

Background: Insulin resistance is a core pathophysiology of polycystic ovary syndrome (PCOS). The screening recommendations for type 2 diabetes in PCOS patients have varied according to organizations, but the AE-PCOS Society recommended that a OGTT be performed in obese patients or in lean patients with advanced age (>40 year), with a history of gestational diabetes, or with a family history of type 2 diabetes. Recently, the American Diabetes Association (ADA) newly includ...

Objective: Insulin resistance is a core feature of polycystic ovary syndrome (PCOS), thus, it may be the common link between PCOS and type 2 diabetes (T2DM).Although the etiology of PCOS has not been elucidated, a number of studies have suggested that genetic factors may play important roles in its etiology and pathogenesis. If PCOS and T2DM share a common genetic background, genetic variants determining the risk of T2DM may also be associated with PCOS....