ea0034oc4.2 | Thyroid and bone | SFEBES2014
Oldknow Karla
, Morton Nik
, Yadav Manisha
, Rajoanah Sophie
, Huesa Carmen
, Bunger Lutz
, Ball Derek
, Ferron Mathieu
, Karsenty Gerard
, MacRae Vicky
, Luis Millan Jose
, Farquharson Colin
Advances in genetic approaches to bone physiology have expanded our understanding of the mechanisms by which bone and energy homeostasis interact. PHOSPHO1, a bone specific phosphatase is essential for the initiation of bone mineralisation. Here we now show that Phospho1 ablation confers a remarkable protection against obesity and diabetes in mice. To understand the mechanism whereby Phospho1 impacts metabolism, microarray analysis of osteoblasts, the primary...