Endocrine Abstracts

Introduction: Central diabetes insipidus (CDI) results from a deficiency of arginine vasopressin (AVP) secretion. It is treated by replacement therapy with the synthetic AVP analogue desmopressin. With atrial distension there is increased afferent vagal stimulation that decreases renal sympathetic tone and inhibits antidiuretic hormone (ADH) release, which in turn leads to the diuresis response. Additionally, atrial distension leads to atrial natriuretic peptide (ANP) release,...