Searchable abstracts of presentations at key conferences in endocrinology

ea0014p577 | (1) | ECE2007

Midnight salivary cortisol vs. urinary free cortisol for the diagnosis of Cushing’s syndrome

Yaneva Maria , Kirilov Georgi , Zacharieva Sabina

Introduction: Midnight salivary cortisol measurement (MSC) has been recently introduced as a diagnostic test for hypercortisolism. The aim of our study was to compare the diagnostic value of two methods of screening for Cushnig’s syndrome (CS): MSC and 24-h urinary free cortisol (UFC), wildely accepted as a ‘gold standard’ for this diagnosis.Patients and methods: Three groups were studied: 30 patients with CS (mean age±S.D.</sm...

ea0070aep172 | Bone and Calcium | ECE2020

Primary hyperparathyroidism diagnosis with 18-F-fluorodioline Pet/CT (FCPCT) in a routine endocrinology praxis: Need of the new guidelines

Schroeder Luc , Smorodova Svetlana , Meilinger Stefan , Münks Sven , Yaneva Maria , Doat Michel , Jonard Florence , Picard Christian , Tikhomirova Maria

Background: Primary hyperparathyroidism (pHPT) is a common disease in a routine endocrinology praxis, but the biggest challenge is a localization of the adenoma and the further correct management of the disease. First FCPCT was reported in 2014 as the additional method of diagnosis of pHPT and in some centers has been already used as a first line diagnostic modality. However, FCPCT is still lacking in the European or International guidelines for the diagnosis of pHPT.<p cl...

ea0026p20 | Adrenal cortex | ECE2011

Clinical presentation of Cushing’s syndrome in a large series from the European Registry on Cushing's syndrome (ERCUSYN)

Valassi Elena , Santos Alicia , Yaneva Maria , Toth Miklos , Strasburger Christian , Chanson Phillippe , Wass John , Chabre Olivier , Pfeifer Marija , Feelders Richard , Tsagarakis Stylianos , Trainer Peter , Franz Holger , Zopf Kathrin , Zacharieva Sabina , Lamberts Steven , Webb Susan

The European Registry on Cushing’s syndrome (ERCUSYN) is designed to collect prospective and follow-up data at EU level on patients with Cushing’s syndrome (CS). Baseline data on 481 CS patients (390 females, 91 males; mean age (±S.D.): 44±14 years) collected from 36 centres in 23 countries. This cohort included new patients since 2008 and retrospective cases since 2005. Patients were divided into four major etiologic groups: pituitary-depend...

ea0022oc3.6 | Pituitary | ECE2010

Young patients with sporadic macroadenomas as target population for AIP mutations screening

Tichomirowa Maria , Barlier Anne , Daly Adrian , Jaffrain-Rea Marie-Lise , Cozzi Renato , Yaneva Maria , Naves Luciana , Ronchi Christina , Sievers Caroline , Maiter Dominique , Montanana Carmen Fajardo , Zacharieva Sabine , Beckers Albert

Methods: We undertook an assessment of patients which were diagnosed with or had their first symptoms of pituitary tumor before the age of 30 and had tumor diameter more than 1 cm without familial history of pituitary adenomas. In patients that consented to genetic analysis, germline mutations in the AIP gene were sought.Results: The study population consisted of 164 patients (61 prolactinomas, 84 somatotropinomas, 16 non-secreting tumors, two pat...

ea0035oc5.1 | Adrenal &amp; Thyroid | ECE2014

Diagnostic and therapeutic outcome in ERCUSYN: Preliminary report in over 1000 patients

Valassi Elena , Santos Alicia , Brue Thierry , Netea-Maier Romana T. , Feelders Richard A. , Yaneva Maria , Tsagarakis Stylianos , Pfeifer Marija , Chanson Philippe , Chabre Olivier , Zopf Kathrin , Toke Judit , Wass John AH , Droste Michael , Maiter Dominique , Dusek Tina , Komerdus Irina , Franz Holger , Lamberts Steven W.J. , Strasburger Christian J.

The European Registry on Cushing’s Syndrome (ERCUSYN) is designed to collect prospective and follow-up data on patients with Cushing’s syndrome (CS) and currently (Sep 2013) includes 1006 patients (804 F, 202 M; mean age (+S.D.) 44.7±13.3 years) from 57 centers in 28 countries.Six hundred and sixty one (66%) had pituitary-dependent CS (PIT-CS), 242 (24%) adrenal-dependent CS (ADR-CS), and 103 (10%) CS from other etiologies, ...

ea0056oc12.5 | Novel aspects of puberty development and Cushing's disease | ECE2018

Diabetes mellitus and muscle weakness are independently associated with mortality in patients with Cushing’s syndrome. Data from ERCUSYN

Valassi Elena , Tabarin Antoine , Brue Thierry , Feelders Richard A , Reincke Martin , Neteia-Maier Romana , Toth Miklos , Yaneva Maria , Webb Susan M , Tsagarakis Stylianos , Chanson Philippe , Pfeifer Marija , Droste Michael , Komerdus Irina , Kastelan Darko , Maiter Dominique , Chabre Olivier , Franz Holger , Santos Alicia , Strasburger Christian J , Trainer Peter J , Newell-Price John , Ragnarsson Oskar

Background: Patients with active Cushing’s syndrome (CS) have increased mortality.Aims: Evaluate cause of death in a large cohort of CS patients, and establish factors associated with increased mortality.Methods: We analysed 1514 patients included in the European Registry on Cushing’s syndrome (ERCUSYN): 1022 (68%) had pituitary-dependent CS (PIT-CS), 379 (25%) adrenal-dependent CS (ADR-CS), 71 (5%) had an ectopic source ...