Searchable abstracts of presentations at key conferences in endocrinology

ea0028p323 | Steroids | SFEBES2012

Mitogen mediated Gc resistance, development of model using serum shock

Yang Nan , Trebble Peter , Matthews Laura , Ray David

Glucocorticoids (Gc) are the most potent anti-inflammatory agents known. A major factor limiting their clinical use is the wide variation in responsiveness to treatment between individuals and over time. Generating a reversible model of Gc resistance in vitro that will mimic the cellular microenvironment in vivo is critical in (i) defining biomarkers that predict patient steroid responsiveness; (ii) provide a model to screen new GR modulators capable of potentiating GR ...