ea0046p11 | (1) | UKINETS2016
Anthony Lowell
, Horsch Dieter
, Ervin Claire
, Kulke Matthew H.
, Pavel Marianne
, Bergsland Emily
, Caplin Martyn
, Oberg Kjell
, Warner Richard
, Kunz Pamela
, Metz David C.
, Pasieka Janice
, Pavlakis Nick
, DiBenedetti Dana
, Haydysch Emily
, Yang Qi Melissa
, Jackson Shanna
, Arnold Karie
, Law Linda
, Lapuerta Pablo
Background: Telotristat etiprate (TE), an oral tryptophan hydroxylase inhibitor, is intended to treat carcinoid syndrome (CS) by reducing serotonin production. TE was evaluated in TELESTAR, a phase 3 study; the primary endpoint showed significant reductions in bowel movement (BM) frequency for 2 TE dosages + standard of care (SOC) vs. SOC. TELESTAR patients had CS inadequately controlled on somatostatin analog therapy with ≥4 BMs per day. They were interviewed about base...