Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep1024 | Thyroid (non-cancer) | ECE2016

Skin autofluorescence and serum carboxymethyllysine levels in hypothyroid and hyperthyroid patients

Yavuz Dilek Gogas , Yazici Dilek , Temizkan Sule

Levels of thyroid hormones may effect the levels of the glycation product and those of the oxidation products.Objective: To evaluate the relationship between skin autofluorescence (SAF), and serum advanced glycation end products (AGEs) parameters in hypothyroid and hyperthyroid patients.Method: Newlydiagnosed or untreated 100 overt and subclinical hypothyroid patients (42±13 yrs) and 50 overt-subclinical hyperthyroid patients ...

ea0035p712 | Neuroendocrinology | ECE2014

Papillary thyroid carcinoma associated with silent paraganglioma: An atypical MEN syndrome?

Tarcin Ozlem , Yazici Dilek , Unal Asli , Demirag Nilgun Guvener

Case: A 51-year-old-woman was referred to endocrinology outpatient clinic due to a thyroid nodule 9 mm in diameter. Fine needle aspiration (FNA) biopsy revealed papillary thyroid carcinoma and she was directed to surgery. The surgeon decided to perform subtotal thyroidectomy due to the small nodule size. Pathologic examination showed the histology to be consistent with tall cell carcinoma. Complementary total thyroidectomy was proposed to the patient but she did not accept the...

ea0020p112 | Thyroid | ECE2009

Preoperative thyroid problems in a cardiovascular hospital

Yazici Dilek , Tuncer Eylem , Mataraci Ilker , Erentug Vedat

Changes in thyroid hormone function may have deleterious effects during cardiovascular surgery. Thus meticulous endocrinology consultation is demanded preoperatively. Thyroid dysfunction may present as subclinical or overt hypothyroidism, subclinical or overt hyperthyroidism, euthyroid sick syndrome, nodular goitre or minor elevations in thyroid hormone levels with normal TSH. The aim of the study was to determine retrospectively the prevelance of thyroid dysfunction in patien...

ea0073aep471 | Pituitary and Neuroendocrinology | ECE2021

Association between fibroblast growth factor-21 and carotid intima media thickness in patients with acromegaly

Uygur Meliha Melin , Yavuz Dilek Gogas , Yazici Dilek

İntroductionThe aim of this study was to evaluate the association between fibroblast growth factor-21 (FGF-21) levels and carotid intima media thickness (CIMT) in acromegalic patients in relation to the atherosclerotic complications.Metarials and methodsThe study goroup included 70 acromegalic patients. According to the disease activity, patients cathegorized inti 2 groups: controlled and active acromega...

ea0090p98 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Investigation of Brain CD47 Expression and Its Relation with Cognitive Functions in Diabetic Mice Models

Kiriscioglu Nil , Asadi Amirhooman , Guven Mucahit , Ozkan Esra , Kocabay Ahmet , Deyneli Oguzhan , Yazici Dilek , Tutuncu Yildiz

Background: Diabetes Mellitus (DM) is an endocrine disorder resulting in hyperglycaemia that affects many vital organs of the body like the brain. The molecular mechanisms underlying dementia, memory loss and cognition dysfunction caused by DM are still not very clear. CD47 is a cell surface protein working in the homeostasis of the immune system. The causal relationship of CD47 has been shown in neurodegenerative diseases. CD47 also has a role in pancreatic islet cells and th...

ea0037ep903 | Thyroid cancer | ECE2015

Familial non-medullary thyroid cancers tend to be more bilateral and have more capsular invasion compared to non-familial ones

Yazici Dilek , Kapran Yersu , Demirkol Onur , Terzioglu Tarik , Tezelman Serdar , Alagol Faruk

Introduction: Currently, about 5–15% of non-medullary thyroid cancers (FNMTC) are considered to be of familial origin. These are either syndrome-associated tumours or non-syndromic tumours. The aim of the study was to determine the clinical, pathological and biochemical characteristics of FNMTC compared to non-familial ones with a follow-up of 10 years.Methods: Among FNMCT followed by a single physician, 62 patients with papillary cancer were screen...

ea0032p848 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Advanced glycation end product associated skin autofluorescence and serum corboxymethyl lysine levels in acromegaly

Yavuz Dilek Gogas , Yalin Serap , Yazici Dilek , Yasar Mehmet , Deyneli Oguzhan

Aim: Nonenzymatic advanced glycation and oxidation end-products, advanced glycation end-products (AGEs), impart a potent impact on vessels in diabetic state and in euglycaemic conditions with increased oxidative stress.The aim of this study is to measure AGEs and its relationship with carotid intimae media thickness (CIMT) in acromegaly patients.Method: A case–control study was performed in 225 acromegalic patients (F/M: 116/1...

ea0020p375 | Diabetes and Cardiovascular | ECE2009

ECoRI polymorphism but not XBaI polymorphism of apolipoprotein B gene is associated with carotis intima media thickness in type 2 diabetic patients

Yuksel Meral , Sancak Seda , Yazici Dilek Dereli , Ozben Beste , Gogas-Yavuz Dilek , Akalin Nefise Sema

ApoB plays a central role in lipoprotein metabolism through regulation of total cholesterol and LDL-cholesterol (LDL-C) concentrations in plasma. Two restriction fragment length polymorphisms (ECoRI and XbaI) represent single base alterations in the coding region of ApoB gene. ECoRI polymorphic region of ApoB gene is due to on an amino acid change (Glu→Lys). The XbaI polymorphic region of ApoB gene results from a substitution of (A→T) in the threonine codon and doe...

ea0014p406 | (1) | ECE2007

Carotid intima media thickness and bone turnover in type 2 diabetic patients

Sancak Seda , Yavuz Dilek , Toprak Ahmet , Deyneli Oguzhan , Tarcin Ozlem , Yazici Dilek , Aydin Hasan , Akalin Sema

Recent studies indicate that atherosclerotic process is associated with bone metabolism. The aim of this study was to evaluate carotid intima media thickness (CIMT) and its association with bone mineral density and bone turnover markers as well as inflammation markers in type 2 diabetic male patients.Material-method: 184 type 2 diabetic males (56±8 y) and 85 non-diabetic control subjects (52±7 y) were recruited. Bone mineral density was measure...

ea0014p415 | (1) | ECE2007

Evaluation of diastolic function and its relationship with carotis intima media thickness and endothelial function in asymtomatic hyperparathyroid patients

Yazici Dilek , Tarcin Ozlem , Ozben Beste , Toprak Ahmet , Deyneli Oguzhan , Sancak Seda , Yavuz Dilek , Akalin Sema

Symptomatic hyperparathyroid patients are under risk of increased cardiovascular mortality, associated with left ventricular hypertrophy, diastolic dysfunction and accelerated atherosclerosis. Data on asymptomatic hyperparathyroid patients are conflicting. This study aimed to determine diastolic dysfunction and its association with carotis intima media thickness (CIMT) and flow-mediated vasodilation (FMD) in a group of asymptomatic hyperparathyroid patients.<p class="abste...