Searchable abstracts of presentations at key conferences in endocrinology

ea0099p551 | Reproductive and Developmental Endocrinology | ECE2024

Endocrine responses to kisspeptin in an unusual case of kallmann syndrome with unilateral anosmia

Tsoutsouki Jovanna , N Comninos Alexander , Phylactou Maria , Patel Bijal , Mills Edouard , Young Megan , Yeung Arthur , Koysombat Kanyada , Modi Manish , Papadopoulou Deborah , Howard Sasha , S Dhillo Waljit , Abbara Ali

Introduction: Kallmann syndrome (KS) is a rare condition characterised by congenital hypogonadotropic hypogonadism (CHH), usually due to defective migration of olfactory axons and GnRH-neurons. KS is typically associated with absent (anosmia) or reduced (microsmia) sense of smell. Unilaterally hypoplastic or absent olfactory bulbs on MRI are reported, although disturbance in smell is usually bilateral. Kisspeptin is a potent stimulator of hypothalamic GnRH-neurons, and endocri...

ea00100oc1 | Oral Communications | SFEEU2024

Making scents of hemi-anosmia in a woman presenting with secondary amenorrhoea

Tsoutsouki Jovanna , Comninos Alexander N , Phylactou Maria , Young Megan , Mills Edouard , Maria Newman Anastasia , Wynn Nyunt Sandhi , Koysombat Kanyada , Yeung Arthur , Patel Bijal , Howard Sasha , S Dhillo Waljit , Abbara Ali

Case history: A 25-year-old woman presented with secondary amenorrhoea present since aged 18yrs. She had spontaneous albeit late menarche aged 16yrs and five menstrual periods over the subsequent two-years, before complete menstrual cessation. She denied other medical history, psychological stress, excessive exercise, or regular medications. Notably, she reported normal sense of smell via her right nostril, but anosmia via her left nostril. Family history included a diagnosis ...

ea00100p21 | Poster Presentations | SFEEU2024

Reversal of congenital hypogonadotrophic hypogonadism (CHH) in a woman with a heterozygous inactivating variant in GnRHR gene

W Nyunt Sandhi , Phylactou Maria , Koysombat Kanyada , Tsoutsouki Jovanna , C Yeung Arthur , Young Megan , Newman Anastasia , N Comninos Alexander , Mamoojee Yaasir , Pitteloud Nelly , Quinton Richard , S Dhillo Waljit , Abbara Ali

Case history: Our patient presented with primary amenorrhoea and incomplete puberty aged 15 yrs. Based on BMI >40 kg/m2 from early adolescence, clinical hyperandrogenism, family history of polycystic ovary syndrome (PCOS), and insulin resistance, she was diagnosed with PCOS and commenced on a combined oral contraceptive (COC), achieving breast development. Aged 21yrs, she was reassessed for amenorrhoea of COC. Biochemical assessment revealed hypogonadotrophic hy...

ea0099oc1.4 | Oral Communications 1: Reproductive and Developmental Endocrinology | ECE2024

Kisspeptin as a test of hypothalamic function in women presenting with oligo / amenorrhoea

Patel Bijal , Abbara Ali , Yeung Arthur , Phylactou Maria , Tsoutsouki Jovanna , Koysombat Kanyada , Young Megan , Nyunt Sandhi , Qayum Ambreen , Patel Aaran , Zielinska Agata , Omar Yusra , Eng Pei , Mills Edouard G , Hanassab Simon , Webber Lisa , Jayasena Channa , Tan Tricia , Quinton Richard , Clarke Sophie , Comninos Alexander , Dhillo Waljit

Background: Polycystic Ovary Syndrome (PCOS) and Functional Hypothalamic Amenorrhoea (FHA) are the two commonest causes of menstrual disturbance in pre-menopausal women. In practice, differentiating these two common reproductive disorders can be challenging. A fundamental abnormality that underpins both conditions is altered gonadotrophin releasing hormone (GnRH) pulsatility, being increased in PCOS but reduced in FHA. Likewise, congenital (e.g. congenital hypogonadotropic hyp...