Searchable abstracts of presentations at key conferences in endocrinology

ea0029s23.3 | Advances in regulation of aldosterone synthesis | ICEECE2012

Role of N-type calcium channel blockers in aldosterone biosynthesis

Yoshimura M.

The inhibition of aldosterone activity is a significant approach for preventing the progression of cardiovascular diseases in hypertensive patients. We hypothesized that N-type calcium channels might regulate aldosterone biosynthesis and firstly examined in vivo studies using rats. We investigated the effects of cilnidipine, an L-/N-type calcium channel blocker (CCB), and nifedipine, an L-type CCB, on aldosterone levels and found that only cilinidipine significantly red...