Searchable abstracts of presentations at key conferences in endocrinology

ea0081p258 | Late-Breaking | ECE2022

Discordant thyroid function tests following Ibrutinib therapy

Yung Zhuang Choo Alwyn , Jayaweera Jayamalee

Background: Tyrosine kinase inhibitors (TKI) are a chemotherapeutic group which include drugs known to cause thyroid dysfunction such as axitinib, imatinib, pazopanib, sorafenib, and sunitinib. However, reports of TKI-Ibrutinib causing thyroid dysfunction are scarce. Although several hypotheses have been proposed to explain TKI-associated thyroid dysfunction there is no clear guidance on how to manage this situation.Case: 86-year-old lady was referred to...

ea0070aep587 | Pituitary and Neuroendocrinology | ECE2020

Pancreatic neuroendocrine tumour with suspected extrarenal secretion of 1,25-dihydroxyvitamin D3

Yung Zhuang Choo Alwyn , Mohammed Kamrudeen

Background: Hypercalcaemia can occur in 20–30% of malignancy. Neuroendocrine malignancy-related hypercalcaemia is relatively rare with few reported cases, mostly in pancreatic neuroendocrine tumours. It could be related to humoral hypercalcaemia of malignancy (PTHrP secretion), production of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) by the tumour or production of PTH by the tumour1,2. Here we describe a case of metastatic neuroendocrine tumour with pos...

ea0094p45 | Neuroendocrinology and Pituitary | SFEBES2023

Phaeochromocytoma/Paraganglioma – Call for Education and More Screening

Yung Zhuang Choo Alwyn , Ahluwalia Rupa , Joseph Neetha , Saada Janak , McArdle Nicholas , Chipchase Allison , Rochester Mark , Manson-Bahr David , Maxwell Melanie , Swe Myint Khin

Background: Phaeochromocytomas & paragangliomas (PPGL) are rare neuroendocrine tumours presenting with symptoms of sympathetic overactivity, hypertension, or as adrenal incidentalomas.Study and results: A 24-year retrospective review of a U.K. single-centre PPGL service (2009 -2023) identified 61 cases (53 phaeochromocytomas/8 paragangliomas). Among these, 35 (57%) were females. Mean age of diagnosis was 56.35±16....