Searchable abstracts of presentations at key conferences in endocrinology

ea0014oc9.6 | Signal transduction | ECE2007

Somatostatin receptor subtype-2 and -3 – selective agonists inhibit insulin secretion from INS-1 cells through modulation of the R-type Ca2+ channel

Mergler Stefan , Singh Vandana , Zacharias Sylvia , Wiedenmann Bertram , Plöckinger Ursula , Strowski Mathias

Objectives: Somatostatin (SST) inhibits insulin secretion from pancreatic B-cells through a reduction of intracellular free calcium ([Ca2+]i). The influx of Ca2+ is mediated by voltage-operated Ca2+ channels (VOCCs). The role of VOCCs of the R-type (CaV2.3) in SST-mediated processes is unknown. Therefore, we designed a study to identify SST-receptor subtypes (SSTR) in insulinoma cells (INS-1) and characterize the role of t...

ea0014p252 | (1) | ECE2007

Somatostatin receptor subtype 2 inhibits glucagon secretion and regulates glucose homeostasis

Strowski Mathias , Singh Vandana , Grötzinger Carsten , Zacharias Sylvia , Wiedenmann Bertram , Plöckinger Ursula

Objectives: Somatostatin (SST) inhibits glucagon and insulin secretion. Five receptor subtypes for SST are known (SSTR1-SSTR5), all of which are expressed in the endocrine pancreas. SSTR2 inhibits glucagon secretion in vitro, however its role in vivo is not well understood. Here, we characterize the role of SSTR2 in regulating glucose homeostasis in mice with diet-induced obesity.Methods: SSTR2-deficient (SSTR2−/−) and control mice...