Searchable abstracts of presentations at key conferences in endocrinology

ea0030p45 | (1) | BSPED2012

Hyperinsulinaemic hypoglycaemia in newborn twins

Mohamed Zainaba , Senniappan Senthil , Hussain Khalid

Background: Newborn infants have multiple risk factors for developing hypoglycaemia of which, hyperinsulinism is an important cause of both transient and persistent hyperinsulinaemic hypoglycaemia (HH). It can present in newborns infants at term, preterm and newborns with intrauterine growth retardation (IUGR). There have been no previous reports of HH occurring in twins and triplets.Aims and objectives: We report the occurrence of HH in 4 sets of twins ...

ea0078p61 | Thyroid | BSPED2021

A rare variant of thyroid hormone receptor beta (THR β) gene mutation in a pre-school child

Sakremath Rajesh , McCrea Kathryn , Patel Kinari , Pogson Linda , Mohamed Zainaba

Introduction: Resistance to thyroid hormone (RTH) is a rare inherited syndrome characterised by refractoriness of target tissue to thyroid hormone. Over 80% of cases are due to mutations in the thyroid hormone receptor beta (THR β) gene with over 100 mutations identified to date. The clinical manifestations vary from common feature as goitre to less common sinus tachycardia, learning disabilities, growth and developmental delay. Aim: We rep...

ea0045p13 | Diabetes | BSPED2016

Practical Elements for Successful Recruitment of Patients and Families with Newly Diagnosed Type 1 Diabetes (T1DM) into a Research Study

Saddington Caroline , Mohamed Zainaba , Sachdev Pooja , Denvir Louise , Randell Tabitha

Background: The paediatric diabetes team at our Children’s Hospital were part of a national clinical trial considering whether long term outcomes are better for patients on MDI (multiple daily injection therapy) or insulin pump therapy from diagnosis. Patients and their families had to be approached, consented and treatment for the trial commenced within two weeks of diagnosis. Many centres struggled to recruit, but this was not the case with our centre.<p class="abst...

ea0095p124 | Gonadal, DSD and Reproduction 2 | BSPED2023

The value of the stimulated testosterone: dihydrotestosterone ratio in 46, XY DSD due to 5alpha-reductase type 2 deficiency

Balagamage Chamila , Igbokwe Rebecca , Idkowiak Jan , Mohamed Zainaba

Introduction: Testosterone(T) is converted to dihydrotestosterone(DHT), the most potent androgen, by the enzyme 5alpha-reductase type 2(SRD5A2). During foetal development, the masculinisation of male external genitalia crucially depends on DHT. Pathogenic variants in SRD5A2 cause 46,XY differences in sex differentiation(DSD). Early and accurate diagnosis is paramount to facilitate gender assignment since most reared as females may profoundly virilize at pubert...

ea0078p57 | Pituitary and Growth | BSPED2021

Rapid-onset obesity, hypothalamic and autonomic dysregulation with neuroendocrine tumours: Can this be ROHHADNET?

Nadar Ruchi , Sakremath Rajesh , Kirk Jeremy , Randell Tabitha , Jenkinson Helen , Woodman Helen , Saraff Vrinda , Mohamed Zainaba

Introduction: ROHHADNET is a rare syndrome characterized by rapid onset obesity, hypoventilation, hypothalamic dysfunction, autonomic dysregulation and neuroendocrine tumours. Although obesity is the first recognisable feature, there is variable onset of other features, resulting in delayed or missed diagnosis, potentially leading to fatal consequences. We describe two cases with features of ROHHADNET, who had high heterogeneity in clinical spectrum. Cas...

ea0051p050 | Pituitary and growth | BSPED2017

Siblings with 3-M Syndrome show good response to Growth Hormone (GH) therapy over a 4 year follow-up growth data

Mohamed Zainaba , Sachdev Pooja , Benson Joanna , Hastings Richard , Randell Tabitha , Denvir Louise

Introduction: 3M syndrome is a rare autosomal recessive condition that causes short stature, unusual facial features and skeletal abnormalities with normal intelligence. Mutations in CUL7, OBSL1 and CCDC8 genes have been identified as pathogenic. GH treatment outcomes for 3M syndrome appear controversial. Use of human recombinant GH for the treatment of short stature has been trialled in previous studies with some suggesting dysregulation in GH/IGF1 axis while others report no...

ea0039ep31 | Diabetes | BSPED2015

Comparison of current trends in obesity in patients with type 1 diabetes in Nottingham with a historical cohort and 2013–2014 national child measurement programme data in the UK

Mohamed Zainaba , Law James , Denvir Louise , Chee Carolyn , Drew Josaphine , Sachdev Pooja , Randell Tabitha

Aim: To compare the BMI z-score of children with type 1 diabetes (T1DM) in Nottingham with that of national and local background populations and to identify factors associated with increased BMI.Methods: A retrospective observational cohort study of patients with T1DM aged 2–15 years under the care of the paediatric diabetes team at Nottingham Children’s Hospital, between April 2013 and March 2014. Mean BMI-z-score for the year was com...

ea0059cc1 | Featured Clinical Cases | SFEBES2018

Pitfalls in the diagnosis of an infant with 46,XX DSD with Congenital Adrenal Hyperplasia due to Cytochrome P450 Oxidoreductase deficiency - the value of simultaneous genetic analysis to the diagnosis in DSD

Idkowiak Jan , Mohamed Zainaba , Allen Stephanie , Chandran Harish , McCarthy Liam , Kirk Jeremy , Cole Trevor , Krone Nils

Background: Congenital adrenal hyperplasia (CAH) is the underlying diagnosis in most newborns presenting with 46,XX disorders of sex development (DSD). Cytochrome P450 oxidoreductase deficiency (PORD) is a rare form of CAH caused by inactivating mutations in the POR gene. The hallmark feature of PORD is combined sex-steroid and glucocorticoid deficiency due to impairment of CYP17A1 and CYP21A2. Skeletal malformations resembling the Antley-Bixler Syndrome phenotype are common i...

ea0036P64 | (1) | BSPED2014

Cellular proliferation is increased in both the lesion and non-lesion pancreas in focal congenital hyperinsulinism

Mohamed Zainaba , Han Bing , Newbould Melanie , Cosgrove Karen , Padidela Raja , Banerjee Indraneel , Dunne Mark J

Introduction: Focal congenital hyperinsulinism (F-CHI) is caused by dual-hit pathology, comprising a paternally-inherited ABCC8/KCNJ11 mutation and somatic loss of the maternal allele at chromosome 11p15. This leads to dysregulation of insulin secretion and β-cell overgrowth with a focal domain.Objectives: To compare the proliferative index (PI) of the F-CHI lesion and non-lesion pancreatic tissues to age-matched control pancreata and insul...

ea0045p4 | Adrenal | BSPED2016

Misleading biochemical picture in infants prior to the confirmatory diagnosis of Congenital Adrenal Hyperplasia (CAH)

Mohamed Zainaba , Benson Joanna , Law James , Denvir Louise , Sachdev Pooja , Randell Tabitha

Introduction: Adrenal insufficiency is a rare cause of life-threatening hyponatraemic collapse in the neonatal period. The initial investigations taken at the time of presentation, and prior to the institution of hydrocortisone, are a key step in the diagnostic pathway.Aim: We present a case series where the initial biochemical test results could have led to a delay in diagnosis or early discontinuation of hydrocortisone.Ca...