Searchable abstracts of presentations at key conferences in endocrinology

ea0037gp.29.02 | Endocrine tumours and neoplasia – Adrenal Tumour | ECE2015

Investigation of a novel liposomal chemotherapy protocol in three preclinical models for adrenocortical carcinoma in vivo

Jung Sara , Reincke Martin , Zambetti Gerard P , Beuschlein Felix , Hantel Constanze

Recently, we demonstrated for adrenocortical carcinoma (ACC) promising antitumoural effects for LEDP-M (etoposide, liposomal doxorubicin, liposomal cisplatin, mitotane) a novel liposomal variant of the classical EDP-M protocol (etoposide, doxorubicin, cisplatin, mitotane). However, clinical translation of novel therapeutic regimens remains challenging due to high tumor heterogeneity. Thus, to obtain preclinical results with more clinically predictive power we investigated for ...