Searchable abstracts of presentations at key conferences in endocrinology

ea0031p197 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2013

DPPIV and macronutrients regulate the expression of PYY3–36 in human gut epithelial cells

Kosicka Anna , Renshaw Derek , Zariwala Mohammed Gulrez

The enzyme dipeptidyl peptidase-IV (DPP-IV) is expressed by gut epithelial cells. DPP-IV cleaves X-proline dipeptides from the N-terminus of polypeptide hormones including GLP-1, GIP and PYY. DPP-IV causes a deactivation of the incretin hormones GLP-1 and GIP, whereas conversely, by converting PYY1–36 to PYY3–36 it allows specific activation of the Y2 receptors in the arcuate nucleus of the hypothalamus leading to hypophagia. Infused PYY3–36 has been ...

ea0028p193 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012

Annexin A1, an anti-inflammatory regulator, is expressed in human adipocytes

Kosicka-Knox Anna , Cunliffe Adam , Mackenzie Richard , Zariwala Mohammed , Renshaw Derek

Annexin A1 (AnxA1), an endogenous glucocorticoid regulated protein, is a pivotal homeostatic regulator of the magnitude of the inflammatory response. We have previously demonstrated that plasma AnxA1 protein is significantly inversely correlated with waist to hip ratio (P=0.017). Given that low-level systemic inflammation is seen in metabolic syndrome-associated chronic pathologies, here, we investigate if AnxA1 is also involved in the regulation of adipose tissue infla...