Searchable abstracts of presentations at key conferences in endocrinology

ea0063p753 | Thyroid 2 | ECE2019

Falsely high serum calcitonin levels

Stojkovic Mirjana , Beleslin Biljana , Ciric Jasmina , Stojanovic Milos , Zarkovic Milos

Calcitonin is a polypeptide hormone synthesized and secreted by the parafollicular cells of the thyroid gland, and has been considered as a good marker for medullary thyroid carcinoma. But several physiologic and pathologic conditions other than medullary thyroid carcinoma have been associated with increased levels of calcitonin. A 39-year old woman was admitted to our hospital for further testing due to high calcitonin level (467 ng/L) measured by immunochemiluminometric assa...

ea0056p1059 | Thyroid (non-cancer) | ECE2018

Metabolic profile in patients with subclinical hypothyroidism

Stojkovic Mirjana , Savic Slavica , Ciric Jasmina , Nedeljkovic-Beleslin Biljana , Stojanovic Milos , Zarkovic Milos

Background: Thyroid function regulates a wide array of metabolic parameters and significantly affects lipoprotein metabolism. Subclinical hypothyroidism (SCH) is the most common thyroid disorder, with a prevalence up to 10% in adult populations. Subclinical hypothyroidism is defined as mild elevation in thyroid stimulating hormones (TSH) in presence of normal free thyroxine (fT4) and free triiodothyronine (fT3). This mild elevation of serum TSH is caused by a minor initial dec...

ea0037ep937 | Thyroid (non-cancer) | ECE2015

Side effects of steroid therapy in Graves' orbitopathy: comparison of two different protocols: parenteral vs combined parenteral and oral

Beleslin Biljana , Ciric Jasmina , Stojkovic Mirjana , Savic Slavica , Ciric Slavica , Lalic Tijana , Nisic Tanja , Stojanovic Milos , Zarkovic Milos

Introduction: Glucocorticoids (GCs) are the treatment of choice for moderate-to-severe and active Graves’ orbitopathy (GO), but optimal treatment is still undefined as serious side effects are great concern of GC therapy. The aim of the present study was to evaluate tolerability and safety of two different treatment protocols.Methods: Consecutive patients were divided according to the protocol of GC therapy into two groups: combined intravenous and ...

ea0022p48 | Adrenal | ECE2010

Combined primary aldosteronism and preclinical Cushing's syndrome due to a large adrenocortical adenoma

Ciric Jasmina , Beleslin Biljana , Stojkovic Mirjana , Trbojevic Bozo , Zarkovic Milos

The rarest causes of primary aldosteronism are aldosterone producing carcinoma, ectopic aldosterone secretion and familial aldosteronism. There are also few cases reported of aldosterone and cortisol tumor cosecretion. We present a 38-year-old woman admitted to our hospital because of resistant hypertension, large adrenal tumor and hypokalemia. At age 32 hypertension was diagnosed, but routine laboratory and abdominal ultrasound examination were normal. Few months before admis...

ea0084op-02-07 | Oral Session 2: Pregnancy | ETA2022

Use of levothyroxine for euthyroid women with positive thyroid antibodies and infertility: Results of thesis (treatment of hypothyroidism in europe by specialists: an international survey)

Negro Roberto , Hegedus Laszlo , Attanasio Roberto , Nagy Endre V. , Papini Enrico , Zarkovic Milos , Perros Petros

Objectives: The use of levothyroxine (LT4) treatment aiming to improve fertility in euthyroid women with positive thyroid peroxidase antibodies (TPOAb), is not supported by the available evidence, however the extent to which this is applied in clinical practice is unknown. The aim of the study was to document the demographic, work-related characteristics, and therapeutic choices of European physicians in the case of euthyroid infertile women positive for TPOAb.<p class="ab...

ea0084ps1-02-12 | Hypothyroidism | ETA2022

Characteristics of specialists delivering clinical care for hypothyroidism in eupope: the “THESIS” study (treatment of hypothyroidism in europe by specialists: an international survey)

Zarkovic Milos , Attanasio Roberto , Hegedus Laszlo , V. Nagy Endre , Negro Roberto , Papini Enrico , Perros Petros

Objectives: Some hypothyroid patients are critical of their care, although this appears to vary between countries. The quality of thyroid care delivered, and the perceived patient experience may be influenced by characteristics of specialists such as age, sex, experience, and workplace setting. Here, we aimed to explore geographical differences in thyroid specialist characteristics.Methods: THESIS is a large European questionnaire survey of thyroid speci...

ea0084ps3-12-111 | Graves’ Disease 2 and Orbitopathy | ETA2022

Circulating marginal zone b cells and IGA serum levels as potential biomarkers of clinical activity of graves’ orbitopathy

Stojkovic Mirjana , Perovic Vladimir , Ciric Jasmina , Beleslin Biljana , Janic Tamara , Popadic Dusan , Zarkovic Milos

Objectives: The Clinical Activity Score (CAS) is used to measure and classify Graves orbitopathy activity (GO). However, CAS is partly subjective, and the evaluation of its components is binary. As CAS is known to be correlated with TSH receptor antibodies (TRAb), we wanted to evaluate other immunological parameters in the peripheral blood as markers of GO activity.Methods: The study included 32 patients (19 females, 13 males). CAS was evaluated by a sin...

ea0090p228 | Thyroid | ECE2023

The role of thyroid autoimmunity in assisted reproduction outcome-not yet solved puzzle

Medenica Sanja , Garalejic Eliana , Abazovic Dzihan , Bukumiric Zoran , Arsic Biljana , Zarkovic Milos

Background: hyroid autoantibodies cross blood-follicle barrier in titer dependent manner and may change oocyte microenvironment with adverse effects on implantation or post-implantation period. Thyroid autoimmunity (TAI) interfers with pregnancy course and newborn anthropometry in pregnancy achieved by assisted reproduction (ART).Objective: To light upon pregnancy course outcomes and newborn anthropometric characteristics regarding TAI in ART programme.<...

ea0049ep1261 | Thyroid (non-cancer) | ECE2017

Therapeutic options in severe thyrotoxicosis with malabsorption

Stojkovic Mirjana , Savic Slavica , Nedeljkovic-Beleslin Biljana , Ciric Jasmina , Nisic Tanja , Zarkovic Milos

Abstract: A 55-year-old woman was admitted to our hospital due to severe hyperthyreosis. She started to feel symptoms of hyper-metabolism four months prior to hospitalization. At that time she was admitted in regional hospital and had gastroenterological examination because of diarrhea. Crohn’s disease was diagnosed and therapy started. At the same time, thyrosupressive therapy started. She had a history of hyperthyreosis thirteen years ago, duodenal hemorrhage ulcer, hyp...

ea0070ep23 | Adrenal and Cardiovascular Endocrinology | ECE2020

Pseudoglandular myxoid adrenal cortical adenoma and secondary hyperaldosteronism

Stojkovic Mirjana , Stojanovic Milos , Nedeljkovic-Beleslin Biljana , Ciric Jasmina , Miletic Marija , Zarkovic Milos

Myxoid adrenocortical adenoma is a rare adenoma originated from adrenal cortex. A 51 years old male patient was admitted to our hospital due to hypertension and hypokalemia. He has a long history of nonregulated hypertension despite multiple antihypertensive medications. Hypokalemia was detected in last two years with potassium levels around 3.0 mmol/l on high supplementation dose up to 10–16 g of KCl/day. He is obese in the past 10 years. His family history was positive...