Endocrine Abstracts

Introduction: The association between vitamin D (25(OH)D) levels and metabolic parameters is not confirmed in some population studies. 25(OH)D concentration in blood is influenced by seasons and this covariate may explain some discordant results. The first aim of our study was to evaluate the prevalence of 25(OH)D deficiency in a population of obesity children (2–18 years) living in the North of Italy (latitude, 45°27′n) with respect to the season. The...

Introduction: Liraglutide, a GLP-1 analogue, is a new option for the treatment of type 2 diabetes (DM2). The purpose of this study was to evaluate the efficacy and safety of liraglutide in daily clinical practice in a heterogeneous population with DM2.Subjects and methods: Four visits were scheduled in a 1 year study (baseline, 4, 8 and 12 months). All patients with a HbA1c not on target (>7%) during an oral hypoglycemic treatment, or patients intole...

Introduction: Liraglutide, a human GLP-1 analogue, is a new option for the treatment of type 2 diabetes (DM2). The purpose of this study was to evaluate the effects of liraglutide on cardiovascular risk factors in daily clinical practice in a heterogeneous population with DM2.Subjects and methods: Four visits were scheduled in a 1 year study (baseline, 4, 8 and 12 months). Patients with a HbA1c not on target (>7%) during an oral hypoglycemic treatmen...

Background: The clinical burden of Klinefelter Syndrome (KS) is not limited to the impairment of gonadal function and an increased prevalence of cardio-metabolic, endocrinological and oncological diseases, but also involve several cognitional, behavioural and psychological issues. Because of the wide heterogeneity in clinical phenotype, the diagnosis of KS is still challenging, resulting in a significant number of patients to remain undiagnosed or to have a late diagnosis. Ver...

Aim: To evaluate: 1) clinical and epidemiological characteristics of outpatients transitioned from Pediatrics Endocrine (PED) to Adult Endocrine Department (AED) in a tertiary Centre; 2) transition process characteristics, and predictive factors of drop-out.Patients and methods: Demographic, clinical, and transition features of 170 consecutive patients with paediatric onset of chronic endocrine or metabolic disease (excluded type 1 diabetes) who transiti...

Aim: The uncertainty on the management of small adrenal incidentalomas (AIs) in guidelines still represents a challenge in real clinical practice. The aim of the study was to identify risk factors for morphological or functional changes during follow-up by using clinical, radiological, and pathological features.Methods: We retrospectively evaluated demographic (gender and age at diagnosis), clinical (weight, height, body mass index, smoking habit, comorb...

Purpose: Diagnosis of adrenal lesions requires hormonal investigation and morphological characterization; when CT and MRI imaging are equivocal, 18F-FDG-PET/CT could be a useful tool, although sensitivity and specificity varied among cohorts. The use of tumour-to-liver maximum standardized uptake values (SUVratio) was found to be accurate, but the best threshold value has not been identified yet. A SUVratio > 1.5 was associated with malignancy with a good performance. The ...

Aim: Prolactinomas are the most frequent pituitary adenomas. Clear predictors of response to dopamine agonists (DA) are still discussed. The purpose of the study was to evaluate the clinical, radiological and hormonal characteristics of PRL-secreting pituitary adenomas, and to evaluate morphological changes over time and predictors of response to DA.Patients and Methods: Patients affected by PRL-secreting adenoma undergoing DA therapy in follow-up in a t...

IntroductionPrimary hypothyroidism, which is one of the main endocrine complications of allogenic stem cells transplantation (allo-SCT), has been largely studied in children. Conversely, data on adults are still limited with a reported incidence widely ranging between 9 and 47%. Older age, multiple allo-SCT, chronic Graft vs Host Disease (cGVHD), prolonged immunosuppressive therapy and high-dose total body irradiation (TBI) have been indicated as potenti...

Hypothyroidism has been traditionally described as a frequent endocrine complication of thalassemic children: in these patients hypothyroidism is mainly of primary origin and not linked to autoimmunity (Mariotti et al., Pediatr Endocrinol Rev 2011). Fewer data are available on the prevalence and nature of this complication in adult age thalassemia. Therefore, we elected to evaluate thyroid function and autoimmunity in a large series of adult patients.<p class="abs...