Searchable abstracts of presentations at key conferences in endocrinology

ea0011p44 | Bone | ECE2006

Selenium supplementation restores the antioxidative capacity and prevents cell damage in mesenchymal stem cells in vitro

Ebert R , Ulmer M , Zeck S , Meissner-Weigl J , Schneider D , Stopper H , Schupp N , Kassem M , Jakob F

Mesenchymal stem cells (MSC) are developed for cell based therapeutic strategies and undergo cellular stress during ex vivo procedures. Reactive oxygen species (ROS) of environmental and cellular origin are involved in redox signaling, cumulative cell damage, senescence and tumor development. Selenium independent (superoxide dismutases 1 and 2 (SOD1 and SOD2) and catalase (CAT)) and selenium dependent (glutathione peroxidases (GPx), thioredoxin reductases (TrxR)) enzyme...