Searchable abstracts of presentations at key conferences in endocrinology

ea0013p131 | Growth and development | SFEBES2007

Basal gene expression patterns in children with growth hormone deficiency or Turner Syndrome

Whatmore Andrew J , Zeef Leo , Clayton Peter E

Children diagnosed with either Growth Hormone deficiency (GHD) or Turner syndrome (TS) are both treated with GH titrated against either weight or area. The response to such treatment however, is highly variable and, at least in part, diagnosis dependent. The precise mechanisms underlying this variability are unknown. As basal GH levels differ between GHD and TS and, as GH elicits its effects through changes in gene expression, the basal gene expression profiles of GHD and TS s...