Searchable abstracts of presentations at key conferences in endocrinology

ea0032p728 | Obesity | ECE2013

Serum- and glucocorticoid-regulated kinase 1 in obesity-related adipose tissue and peripheral inflammation

Reiter Marie Helene , Kiefer Florian , Zeyda Maximilian , Kopecky Chantal , Stulnig Thomas , Luger Anton , Vila Greisa

The serum- and glucocorticoid-regulated kinase 1 (Sgk1) is a direct transcriptional target of glucocorticoids and is post-translationally activated by the insulin/IGF1 pathway. Distinct polymorphisms in the Sgk1 gene are associated with increased body weight and type 2 diabetes. Here we investigate the expression and regulation of Sgk1 in human obesity.In both omental and subcutaneous human adipose tissue, Sgk1 expression is significantly increased in 20...

ea0022p717 | Obesity | ECE2010

Characterisation of serum and glucocorticoid-induced kinase 1 in adipose tissue

Vila Greisa , Kiefer Florian , Reiter Marie Helene , Zeyda Maximilian , Stulnig Thomas M , Luger Anton

Serum and glucocorticoid-induced kinase 1 (Sgk1) is an early transcriptional target of glucocorticoids with antiapoptotic effects. Sgk1 becomes active after phosphorylation by growth factors such as insulin and IGF1 through the PI3 kinase/PDK1 pathway. Activated Sgk1 increases the cellular uptake of glucose by increasing the membrane abundance of glucose transporters GLUT1 and GLUT4. Here we present data on the expression and regulation of Sgk1 in adipose tissue using three di...