Searchable abstracts of presentations at key conferences in endocrinology

ea0063p315 | Reproductive Endocrinology 1 | ECE2019

Pituitary tumor as a cause of male infertility

Jankowska Katarzyna , Zgliczyński Wojciech

Context: Pituitary tumor can cause infertility. It can be hormonally active adenoma (mostly prolactinoma) or hormonally inactive. Hyperprolactinemia is the most common disorder. Prolactin interferes with pulsatile secretion of the hypothalamus gonadoliberin (GnRH) and consequent pituitary gonadotropins (FSH and LH), and then leads to abnormal gonadal function. As a result, a man gets impaired spermatogenesis and endocrine function of the testicles. Infertility and reduced test...

ea0081ep733 | Pituitary and Neuroendocrinology | ECE2022

Analysis of the causes and frequency of discrepancies between GH and IGF-1 levels in patients with acromegaly based on the polish register of acromegaly patients

Ostrowska Magdalena , Tomasik Agnieszka , Zgliczyński Wojciech , Glinicki Piotr

Introduction: Acromegaly is a rare disease of the pituitary gland. Both GH and IGF-1 levels are of key importance for monitoring of treatment effects in patients with acromegaly. In some patients, divergent results of measurements of these hormones are observed. Purpose: The purpose of the study was to estimate frequency of GH and IGF-1 inconsistencies in the population of patients with acromegaly included in the Polish Register of Acromegaly Patients, a...

ea0070aep128 | Bone and Calcium | ECE2020

Ultrasound-guided laser thermal ablation for parathyroid adenomas - preliminary report

Kochman Magdalena , Waldemar Misiorowski , Wojciech Zgliczyński

Background: The curative therapy of primary hyperparathyroidism (pHPT) is surgery. Data about ultrasound-guided laser ablation (LA) of parathyroid tumor are limited, however it could be a solution for patients with high surgery or anesthetic risk. We report our experience on LA of parathyroid tumors in 11 patients with pHPT with high surgery or anesthetic risk.Methods: LA was performed under ultrasound guidance with an output power of 3W. Total energy an...

ea0073aep492 | Pituitary and Neuroendocrinology | ECE2021

GH and IGF-1 discrepancies in acromegaly patients after pituitary surgery – an observational single-center study

Tomasik Agnieszka , Maria Stelmachowska-Banaś , Wojciech Zgliczynski

IntroductionTreatment of choice in acromegaly is transsphenoidal resection of GH-secreting pituitary adenoma. Its efficacy ranges from 28% to 83% depending on tumor size and location. Random GH < 1 µg/l or nadir GH in OGTT < 0.4 µg/l and normal IGF-1 are found to be the evidence of effective surgery. However, some patients diagnosed with acromegaly remission after surgery present discordant GH and IGF-1 results.Ai...

ea0081p131 | Endocrine-Related Cancer | ECE2022

Neuropeptide Y (NPY) and Human cocaine- and amphetamine-regulated transcript (CART) in patients with adrenal pheochromocytoma

Glinicki Piotr , Ostrowska Magdalena , Papierska Lucyna , Szatko Alicja , Zgliczyński Wojciech

Introduction: Pheochromocytoma is a rare tumor that develops from chromaffin cells of the adrenal medulla. In about 90% of cases, it is a benign tumor. Along with catecholamines, neuroendocrine cells of the adrenal medulla have the ability to produce various proteins and neuropeptides and secrete them into the blood. Among the known biologically active substances are: neuropeptide Y and human cocaine- and amphetamine-regulated transcript (CART).Purpose: ...

ea0090p387 | Endocrine-related Cancer | ECE2023

Don’t let your guard down – aggressive, hereditary paraganglioma associated with SDHD gene nonsense variant: c.33C>A (p.(Cys11Ter))

Szatko Alicja , Leszczynska Dorota , Woźniak Beata , Papierska Lucyna , Zgliczyński Wojciech , Glinicki Piotr

Introduction: Paragangliomas belong to the neuroendocrine tumours arising from autonomic nervous system. Various localizations, symptoms that can mimic a wide range of diseases and often unpredictable ability to metastasize are the reasons why paragangliomas pose a significant diagnostic challenge. More than one third of paragangliomas is associated with germline mutations –succinate dehydrogenase (SDH) subunit genes are among the most common susceptibility genes. SDHD wa...

ea0070ep293 | Pituitary and Neuroendocrinology | ECE2020

Pasireotide LAR in acromegaly resistant to first generation somatostatin analogs – single-center prospective interventional study

Majos Agnieszka , Stelmachowska-Banaś Maria , Czajka-Oraniec Izabella , Zgliczyński Wojciech

Introduction: The treatment of choice in persistent acromegaly after transsphenoidal adenomectomy is pharmacological treatment with first generation somatostatin analogs. They are effective in 25% to 45% of patients. Second generation somatostatin analog – pasireotide seems to be more effective.Aim: The aim of the study was to assess the efficacy and safety of pasireotide LAR in acromegaly patients resistant to first generation somatostatin analogs...

ea0070aep294 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Fibroblast growth factor 21 (FGF21) in hyper- and hypothyroidism, association with metabolic disturbances

Szczepańska Ewa , Gietka-Czernel Małgorzata , Glinicki Piotr , Jastrzębska Helena , Słowińska-Srzednicka Jadwiga , Kapuścińska Renata , Zgliczyński Stefan , Zgliczyński Wojciech

Background: FGF21 is a critical metabolic regulator with beneficial effects on lipid and glucose metabolism. FGF21 is produced primarily by the liver and stimulates fatty acids oxidation, which prevents hepatic triglycerides accumulation and nonalcoholic fatty liver disease (NALFD). FGF21also increases insulin sensitivity and glucose uptake in adipose tissue. Paradoxically FGF21 is elevated in insulin resistance states e.g. NALFD, obesity and type 2 diabetes. It is not determi...

ea0073aep686 | Thyroid | ECE2021

Comparison of body composition and insulin sensitivity changes in patients with Graves disease after radioiodine or antithyroid drugs treatment

Ewa Szczepanska , Glinicki Piotr , Wojciech Zgliczynski , Helena Jastrzębska , Jadwiga Slowinska-Srzednicka , Renata Kapuścinska , Stefan Zgliczynski , Malgorzata Gietka-Czernel

Thyroid hormones (TH) are key regulators of basal metabolic rate and body weight. They increase resting energy expenditure by increased synthesis of uncoupling protein-1 (UCP-1) in brown adipocytes which stimulates energy dissipation as a heat. TH also increase appetite by central adrenergic stimulation. Body weight change is a key symptom of thyroid dysfunction especially the weight gain observed in patients treated for hyperthyroidism AIM: To compare the influence of differe...

ea0081rc6.5 | Rapid Communications 6: Endocrine-Related Cancer | ECE2022

Granin family peptides and INSM-1 (Insulinoma-associated protein 1) in the biochemical diagnosis of pheochromocytoma

Glinicki Piotr , Ostrowska Magdalena , Stelmachowska-Banas Maria , Papierska Lucyna , Szatko Alicja , Kowalski Konrad , Zgliczyński Wojciech

Introduction: Pheochromocytoma is a rare, usually benign tumor composed of neuroendocrine (chromaffin) cells of the adrenal medulla. It is the cause of secondary arterial hypertension. The biochemical diagnosis of a pheochromocytoma is based on the determination of concentration/excretion of catecholamine metabolites in blood or urine. The most sensitive biomarkers in the biochemical diagnosis of pheochromocytoma are plasma free methanephrines (metanephrine, normetanephrine an...