Searchable abstracts of presentations at key conferences in endocrinology

ea0013p152 | Diabetes, metabolism and cardiovascular | SFEBES2007

Effect of SOM230 on the proliferation of adult human vascular endothelial cells

Li Chao , Zhong Wenwen , Xu Shang-Zhong , Atkin Stephen L

SOM230 is one of the long-acting somatostatin analogues, which has been developed for the treatment of neuroendocrine tumours. Recently we found that SOM230 inhibits the proliferation of human umbilical vein endothelial cells (HUVECs). The aim of this study is to further investigate its antiproliferative effect using adult human aortic endothelial cells (HAECs) and human dermal microvessel endothelial cells (HDMECs). The expression of SSTRs and the potential mechanism were obs...

ea0013p150 | Diabetes, metabolism and cardiovascular | SFEBES2007

Bcl-2 upregulation mediates the protective effect of fluvastatin against oxidative damages in human vascular endothelial cells

Xu Shang-Zhong , Zhong Wenwen , Lindow Steve , Newton Christopher , Atkin Stephen L

Many evidences have shown that the beneficial effect of statins on the cardiovascular disease may be not only due to their cholesterol-lowering, but also may result from their non-lipid related effects, such as the improvement of endothelial function, the inhibition of smooth muscle proliferation, etc\. Here we investigated the effect of fluvastatin on H2O2-induced oxidative cell damage and the underlying mechanism in human umbilical vein endothelial cell...