Endocrine Abstracts

Introduction: The SAGIT instrument was developed for clinicians to assess the status and evolution of the disease in patients with acromegaly. Currently, it is investigated in the validation phase. The aim of our study was to evaluate the potential utility of SAGIT instrument for distinguishing acromegaly clinical stages and its usefulness in treatment decision-making at a single Polish endocrine center.Patients and Methods: Medical charts of adults with...

Diagnosis and treatment of Cushing’s disease is one of the greatest challenges of modern endocrinology. This is related to the fact that pituitary corticotropinomas are small tumours that are difficult to visualize in magnetic resonance imaging (MR). In about 40% of patients with Cushing’s disease, MR scans of the pituitary gland do not reveal any changes. The method that allows to localize the source of adrenocorticotropin (ACTH) secretion is bilateral inferior pe...

Background: TMEM127 encodes for a ubiquitously expressed transmembrane protein with limited knowledge into its role. TMEM127 germline loss-of-function is a driver of pheochromocytoma and paraganglioma (PPGLs), tumors derived from the adrenal medulla and extra-adrenal paraganglia, respectively. Molecularly, TMEM127 mutant PPGLs belong to the kinase cluster, characterized by kinase signaling transcriptional programs. Receptor tyrosine kinase RET, a driver of PPGLs via germline o...