Searchable abstracts of presentations at key conferences in endocrinology

ea0081p15 | Adrenal and Cardiovascular Endocrinology | ECE2022

Decreased steroidogenic enzymes activity in benign adrenocortical tumors is more pronounced in bilateral lesions as determined by steroid profiling in HPLC-MSMS during ACTH stimulation test

Fideline Bonnet , Barat Maxime , Vaczlavik Anna , Jouinot Anne , Bouys Lucas , Laguillier-Morizot Christelle , Zientek Corinne , See Catherine , Larger Etienne , Guignat Laurence , Groussin Lionel , Assie Guillaume , Guibourdenche Jean , Nicolis Ioannis , Menet Marie-Claude , Bertherat Jerome

Objective: Large response of steroids precursors, including 17-hydroxyprogesterone and 11-deoxycortisol, to ACTH has been described in adrenocortical tumors, suggesting the existence of intra-tumoral enzymatic deficiencies. This study aimed to compare steroidogenic enzymes activity in unilateral and bilateral benign tumors using serum steroid profiling in HPLC-MS/MS in basal state and after ACTH 1-24 stimulation.Design and Methods: A serum profile of sev...

ea0090rc6.6 | Rapid Communications 6: Endocrine-related Cancer | ECE2023

C-peptide level concomitant with hypoglycemia gives better performances than insulin for the diagnosis of endogenous hyperinsulinism: a monocentric study of 159 fasting trials

Fideline Bonnet , Devin Clara , Thomeret Louis , Laguillier-Morizot Christelle , Leguy Marie-Clemence , Vaczlavik Anna , Bouys Lucas , Zientek Corinne , Bricaire Leopoldine , Bessiene Laura , Guignat Laurence , Libe Rossella , Mosnier-Pudar Helen , Assie Guillaume , Groussin Lionel , Guibourdenche Jean , Bertherat Jerome

Introduction: The gold standard for insulinoma diagnosis is still 72-hours fasting trial with the aim to trigger WhippleÂ’s triad. In this context, biological diagnosis of endogenous hyperinsulinism relies on the occurrence of a hypoglycemia, concomitant with inadequate high insulin and C-peptide levels. However, diagnostic cut-offs are not consensual among the different learned societies (Endocrine Society 2009, NANETS 2010, ENETS 2012). The objective of this wor...