Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep851 | Reproductive and Developmental Endocrinology | ECE2022

Eunuchoid skeletal proportions in male hypogonadism: a comparative analysis of anthropometric measures between men with congenital hypogonadotropic hypogonadism (CHH) and Klinefelter Syndrome (KS)

De Vincentis Sara , Corleto Rossella , Bellelli Alessio , Zirilli Lucia , Santamaria Emanuele , Granata Antonio , Rochira Vincenzo

Background: Patients with CHH and KS have eunuchoid body proportions of the skeleton compared to normal male subjects, characterized by tall stature, and reduced upper-to-lower segment ratio (U/l). Vice versa, steroids exposure deeply differs between CHH and KS at puberty, with both testosterone and estradiol being very low only in CHH. At present, body skeletal proportions comparison between CHH and KS is not available.Aim: To compare anthropom...

ea0032p881 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Effects of gender and body composition on GH response to GHRH+Arg in HIV-lipodystrophic patients: higher rate of GH deficiency in men

Brigante Giulia , Diazzi Chiara , Ferrannini Giulia , Ansaloni Anna , Zirilli Lucia , Guaraldi Giovanni , Rochira Vincenzo

Background: SUB:Pituitary – Clinical (Generously supported by IPSEN)GH response to GHRH+Arg is impaired in HIV-infected men and women, compared to gender matched controls. Moreover, reduced GH secretion seems to occur more frequently in HIV-infected males than females.Methods: To determine gender effects on GH secretion in HIV-infected patients with lipodystrophy, we compared GH/IGF1 status and body composition in 103 males and 97 females. ...

ea0022p531 | Male reproduction | ECE2010

Prevalence and characterization of hypogonadism among men with human immunodeficiency virus infection: preliminary results

Rochira Vincenzo , Brigante Giulia , Santi Daniele , Zirilli Lucia , Diazzi Chiara , Orlando Gabriella , Carani Cesare , Guaraldi Giovanni

Introduction: Among various comorbidities of human immunodeficiency virus-1 (HIV-1) infection, male hypogonadism is very frequent with a prevalence of 19% in patients treated with highly active anti-retroviral therapy. However, literature data are still lacking and achieved by studies with <300 subjects each.Aim of the study: Prevalence and clinical characterization of hypogonadism among a large number of men with HIV-1.Methods...

ea0022p788 | Thyroid | ECE2010

Role of calcitonin (Ct) in wash-out fluid from fine-needle aspiration (FNAB) in the diagnosis of medullary thyroid cancer (MTC): comparison with basal calcitonin, cytology and pentagastrin stimulation test (Pg-Test)

Rochira Vincenzo , Diazzi Chiara , Zirilli Lucia , Romano Stefania , Carani Cesare , Madeo Bruno

Introduction: Serum Ct is considered the most sensitive tool for MTC screening, but with poor specificity. Pg-test sensitivity and specificity are high, but doubtful for 30–100 pg/ml of Ct peak. FNAB is not routinely used due to its very low sensitivity and specificity. Only few studies from a small number of patients are available on the role of Ct measurement in the wash-out fluid (Ct-FNAB) for MTC diagnosis, providing conflicting results.Aim of t...

ea0020p596 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

GH deficiency in HIV-infected patients with lipodystrophy: preliminary data on the effects of r-hGH treatment on body composition

Zirilli Lucia , Orlando Gabriella , Brigante Giulia , Squillace Nicola , Diazzi Chiara , Carani Cesare , Guaraldi Giovanni , Rochira Vincenzo

Introduction: HIV-infected patients often display a moderate to severe GH deficiency (GHD). To investigate the effects of r-hGH on hormonal parameters and body composition in patients with HIV-related lipodystrophy (HIV-r-L) and concomitant GHD, we studied 60 patients with HIV-r-L, 28 male and 32 females aged 18–65 years. According to their response to GHRH+Arginine (GH peak assumed to be normal when >7.5 ng/ml) patients were assigned to the following 3 groups: Group ...

ea0014p645 | (1) | ECE2007

Effect of age and testosterone on sleep related erections

Granata Antonio R M , Rochira Vincenzo , Madeo Bruno , Pugni Valeria , Zirilli Lucia , Carani Cesare

Introduction: In order to study the effect of age and testosterone on sleep related erections, we enrolled 209 men (122: age 30–49 years; 87: age over 50 years), including mild and severe hypogonadal subjects (129) and eugonadal subjects (80).Subjects and methods: The subjects were assigned to four groups, according to their testosterone serum levels. All the subjects underwent nocturnal penile tumescence and rigidity monitoring (NPTRM). The followi...

ea0016p137 | Clinical cases | ECE2008

A novel compound heterozygous mutation of the aromatase gene in adult man: new insight into the role of estrogen on gonadal development

Lanfranco Fabio , Zirilli Lucia , Baldi Matteo , Luberto Alessandra , Pignatti Elisa , Magnani Francesca , Aimaretti Gianluca , Carani Cesare , Rochira Vincenzo

We present a novel heterozygous compound inactivating mutation of the CYP19A1 (P450arom) gene in a 26-year-old 46-XY Caucasian Italian male leading to aromatase deficiency. The patient phenotype resembled those observed in the other estrogen-deficient patients: tall stature with continuing linear growth, bilateral genu valgum, unfused epiphyses and delayed bone age, osteopenia. A dysmetabolic syndrome characterized by overweight (BMI 29), hyperinsulinaemia, low serum HDL and i...

ea0016p447 | Neuroendocrinology | ECE2008

GH response to GH-releasing hormone–arginine (GHRH+Arg) is impaired in women affected by human immunodeficiency virus (HIV)-related lipodystrophy

Rochira Vincenzo , Zirilli Lucia , Orlando Gabriella , Scaltriti Sara , Squillace Nicola , Diazzi Chiara , Esposito Roberto , Carani Cesare , Guaraldi Giovanni

Context: Lipodystrophic HIV patients frequently display impaired pituitary GH response. Objective. To investigate the GH response to GHRH+Arg in women with HIV-related lipodystrophy (HARS) compared with healthy females. To identify possible predictive factors for such a GH response in these patients.Patients: Forty-nine female patients with HARS were compared with 10 healthy women matched for age and BMI.Methods: Patients and contr...

ea0016p766 | Thyroid | ECE2008

Higher prevalence of nodular goiter and thyroid carcinoma in patients with familial adenomatous poliposis (FAP)

Zirilli Lucia , Romano Stefania , Madeo Bruno , Carani Cesare , Benatti Piero , De Leon Maurizio Ponz , Roncucci Luca , Rochira Vincenzo

FAP is a dominant autosomic syndrome, due to mutation of the APC oncosuppressor gene, characterised by adenomatous polyps at the colon–rectal level, that progres to malignant degeneration. FAP extraintestinal manifestations include, although rare, the thyroid nodules and tumours. Neck ultrasound (US) is routinely useful to identify thyroid nodules, but the characterisation of their nature requires the cytology by a FNAb. The exact incidence of the thyroid tumours on FAP s...

ea0092ps1-09-03 | Thyroid Cancer | ETA2023

Prophylactic bilateral central neck dissection does not improve the short term response to surgery and radioiodine ablation in differentiated thyroid cancer

Piccinini Francesca , Madeo Bruno , Zirilli Lucia , Zanni Eleonora , Sueri Roberta , Loiacono Simona , Rochira Vincenzo , Simoni Manuela , Brigante Giulia

Background: The use of prophylactic central neck dissection, especially for low-risk differentiated thyroid cancer, is still very variable from center to center. Obviously, central dissection does allow more complete staging of cancer, including identification of metastases not detectable on preoperative ultrasound. However, it could lead to higher risk of hypoparathyroidism. Above all, it is not entirely clear whether the identification of metastases of the central compartmen...