Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep887 | Thyroid | ECE2020

Vitamin D supply influences negatively the serum IL-6 and IL-17A levels in Hashimoto’s thyroiditis, while positively the serum antibody levels against thyroid peroxidase and TSH receptor in Graves’ disease

Molnár Ildikó , Nagy Zoltán

Vitamin D plays an important role in the adaptive and innate immunity besides its skeletal effects. Some autoimmune disease is associated with vitamin D deficiency highlighting its crucial involvement in the onset of autoimmune diseases. This study investigated the relationship between the vitamin D supply and the serum IL-6, IL-17A and antibody levels against thyroid peroxidase (TPO) and TSH receptor in autoimmune thyroid diseases. Serum IL-6, IL-17A and antibody levels again...

ea0014p141 | (1) | ECE2007

Thyroglobulin-antibodies in the “normal” range may decrease the diagnostic accuracy of thyroglobulin in the care of patients with differentiated thyroid cancer

Zoltán Locsei , Erzsébet Toldy , István Szabolcs , Gábor Kovács L.

Issue: The use of thyroglobulin (Tg) as tumor marker in differentiated thyroid cancer (DTC) is limited in the presence of thyroglobulin-antibodies (TgAb) but it is generally believed that this is true only for TgAb concentrations over the normal ‘cut off’ point.The aim: Of this study was to investigate if TgAb-s in the normal range, considered to be physiological, may also influence the accuracy and clinical relevance of Tg measurement.<p c...

ea0070aep920 | Thyroid | ECE2020

Retrospective analysis of low risk thyroid cancers. Total thyroidectomy or lobectomy is the optimal approach for follow up?

Hella Zoltán , Vass László , Csapó Zsolt , László Kovács Gábor

Background: Differentiated thyroid cancer (DTC) <1 cm without risk factors require only lobectomy, and there is no need for radioiodine remnant ablation (RRA). The approach for surgery and RRA after surgery is less clearly defined for tumours measuring 1–4 cm.Objectives: We aimed to evaluate the surgical approaches of DTC in stages pT1–2 in a moderate iodine deficient area. We compared our data to the current European Thyroid As...

ea0070aep974 | Thyroid | ECE2020

Humoral changes during resolution of short term severe hypothyroidism

Gergics Marin , Pham-Dobor Greta , Horváth-Szalai Zoltán , Kőszegi Tamás , Mezosi Emese , Bajnok Laszlo

Introduction: Significant hyponatremia may evolve in hypothyroidism, when however, elevated ADH levels have not been consistently demonstrated. On the other hand, it was shown that thyroid hormone substitution suppresses ADH, and its surrogate marker copeptin secretion. The aim of our present study was to investigate the possible humoral changes in a special model of resolution of short term severe hypothyroidism in differentiated thyroid cancer (DTC) patients.<p class="ab...

ea0014p220 | (1) | ECE2007

Antipsychotic drugs and associated metabolic disorders

Melinda Kolcsár , Réka Nagy , Imre Nagy , Annamária László , Zoltán Kun Imre

Obesity is a major contributor to a range of metabolic disorders responsible for much of the medical morbidity and mortality. Increasing numbers of reports concerning not only obesity, but diabetes, hyperglycaemia and lipid dysregulation in patients treated with antipsychotics have raised concerns about a possible association between these metabolic effects and treatment with these medications. The objective of our study was to investigate the prevalence of obesity and other m...

ea0070aep149 | Bone and Calcium | ECE2020

Investigation of total- and free-25OHD levels by different methods in pregnant women

Tüttő Ágnes , Balázs Karvaly Gellért , Gerszi Dóra , Várbiró Szabolcs , Lőcsei Zoltán , Konderak Judit , Toldy Erzsébet

Avoiding vitamin D deficiency can be beneficial in prevention of adverse maternal, fetal and neonatal outcomes. Because of increasing level of vitamin D-binding protein (DBP) in pregnancy, the determination of free-25OHD should be required, whose adequate measure is a challenge for the analytics. Literature data are contradictory whether total-or free-25OHD fraction is more reliable taking into consideration the methods of measurement. Data of publications on free or total, bi...

ea0070aep150 | Bone and Calcium | ECE2020

Analysis of 25OHD levels in chronic renal failure depending on the methods

Toldy Erzsébet , Konderak Judit , Kovács László , Tüttő Ágnes , Balázs Karvaly Gellért , Lőcsei Zoltán

Vitamin D deficiency is common in patients with chronic renal failure (CRF) based on routinely determined total-25-hydroxyvitaminD (t-25OHD) levels. The present knowledge is contradictory whether the direct measured free-25OHD (dm_f-25OHD) or the calculated free-25OHD (c_f-25OHD) is the best indicator of the vitamin D supply for CRF patients. Adding methods to our previously described first experiences on this subject, in this study we aimed to serve newer data to make this qu...

ea0070aep533 | Endocrine-related Cancer | ECE2020

Follow-up case report of an endoscopic ultrasound-guided ethanol ablation: An alternative option for the treatment of pancreatic insulinoma

Vágvölgyi Anna , Nagy Rea , Bor Renáta , Fábián Anna , Sepp Krisztián , Hamar Sándor , Tiszlavicz László , Szepes Zoltán , Valkusz Zsuzsanna

Insulinomas are predominantly benign pancreatic neuroendocrine tumors presenting with hyperinsulinemic hypoglycemia. Patients with significant hypoglycemic episodes can pose a management challenge. Based on the extent and the aggressiveness of the disease patients may be offered different treatment regimens. Although surgical resection is currently the standard treatment for pancreatic insulinoma, alternative treatment options, such as endoscopic ultrasound-guided fine needle ...

ea0070ep285 | Pituitary and Neuroendocrinology | ECE2020

Acromegaly and glucose metabolism – A case report

Denes Judit , Hargittay Csenge , Hubina Erika , Görömbey Zoltán , Oláh Dóra , Kovács László , Góth Miklós

Acromegaly is a rare disorder caused by growth hormone (GH) and insulin-like growth factor I (IGF-I) overproduction, associated with increased morbidity and mortality. It has different complications, among which insulin resistance, prediabetes and diabetes mellitus are substantial. GH affects glucose metabolism through different mechanisms. The therapy of GH overproduction (for example surgical or radiotherapy) improves glucose metabolism, while different types of medical ther...

ea0014p557 | (1) | ECE2007

Comparative analysis of reactivity of macroprolactin in first and second-generation prolactin assays

Rigó Erzsébet , Toldy Erzsébet , Löcsei Zoltán , Toldy Erzsébet , Szabolcs István , Kovács Gábor L.

Issue: Macroprolactin (MPRL) is a high molecular mass complex of prolactin with minimal bioactivity in vivo that may be the cause of elevated serum prolactin (PRL) as determined by immunoassay. Unrecognised macroprolactinemia can lead to misdiagnosis and mistreatment. The frequency of MPRL is highly dependent on the affinity of the antibody used in the assay.The aim of this study: Was to compare the frequency and quantity of MPRL measured by a first and ...