Endocrine Abstracts

Vitamin D plays an important role in the adaptive and innate immunity besides its skeletal effects. Some autoimmune disease is associated with vitamin D deficiency highlighting its crucial involvement in the onset of autoimmune diseases. This study investigated the relationship between the vitamin D supply and the serum IL-6, IL-17A and antibody levels against thyroid peroxidase (TPO) and TSH receptor in autoimmune thyroid diseases. Serum IL-6, IL-17A and antibody levels again...

Issue: The use of thyroglobulin (Tg) as tumor marker in differentiated thyroid cancer (DTC) is limited in the presence of thyroglobulin-antibodies (TgAb) but it is generally believed that this is true only for TgAb concentrations over the normal ‘cut off’ point.The aim: Of this study was to investigate if TgAb-s in the normal range, considered to be physiological, may also influence the accuracy and clinical relevance of Tg measurement.<p c...

Background: Differentiated thyroid cancer (DTC) <1 cm without risk factors require only lobectomy, and there is no need for radioiodine remnant ablation (RRA). The approach for surgery and RRA after surgery is less clearly defined for tumours measuring 1–4 cm.Objectives: We aimed to evaluate the surgical approaches of DTC in stages pT1–2 in a moderate iodine deficient area. We compared our data to the current European Thyroid As...

Introduction: Significant hyponatremia may evolve in hypothyroidism, when however, elevated ADH levels have not been consistently demonstrated. On the other hand, it was shown that thyroid hormone substitution suppresses ADH, and its surrogate marker copeptin secretion. The aim of our present study was to investigate the possible humoral changes in a special model of resolution of short term severe hypothyroidism in differentiated thyroid cancer (DTC) patients.<p class="ab...

Obesity is a major contributor to a range of metabolic disorders responsible for much of the medical morbidity and mortality. Increasing numbers of reports concerning not only obesity, but diabetes, hyperglycaemia and lipid dysregulation in patients treated with antipsychotics have raised concerns about a possible association between these metabolic effects and treatment with these medications. The objective of our study was to investigate the prevalence of obesity and other m...

Avoiding vitamin D deficiency can be beneficial in prevention of adverse maternal, fetal and neonatal outcomes. Because of increasing level of vitamin D-binding protein (DBP) in pregnancy, the determination of free-25OHD should be required, whose adequate measure is a challenge for the analytics. Literature data are contradictory whether total-or free-25OHD fraction is more reliable taking into consideration the methods of measurement. Data of publications on free or total, bi...

Vitamin D deficiency is common in patients with chronic renal failure (CRF) based on routinely determined total-25-hydroxyvitaminD (t-25OHD) levels. The present knowledge is contradictory whether the direct measured free-25OHD (dm_f-25OHD) or the calculated free-25OHD (c_f-25OHD) is the best indicator of the vitamin D supply for CRF patients. Adding methods to our previously described first experiences on this subject, in this study we aimed to serve newer data to make this qu...

Insulinomas are predominantly benign pancreatic neuroendocrine tumors presenting with hyperinsulinemic hypoglycemia. Patients with significant hypoglycemic episodes can pose a management challenge. Based on the extent and the aggressiveness of the disease patients may be offered different treatment regimens. Although surgical resection is currently the standard treatment for pancreatic insulinoma, alternative treatment options, such as endoscopic ultrasound-guided fine needle ...

Acromegaly is a rare disorder caused by growth hormone (GH) and insulin-like growth factor I (IGF-I) overproduction, associated with increased morbidity and mortality. It has different complications, among which insulin resistance, prediabetes and diabetes mellitus are substantial. GH affects glucose metabolism through different mechanisms. The therapy of GH overproduction (for example surgical or radiotherapy) improves glucose metabolism, while different types of medical ther...

Issue: Macroprolactin (MPRL) is a high molecular mass complex of prolactin with minimal bioactivity in vivo that may be the cause of elevated serum prolactin (PRL) as determined by immunoassay. Unrecognised macroprolactinemia can lead to misdiagnosis and mistreatment. The frequency of MPRL is highly dependent on the affinity of the antibody used in the assay.The aim of this study: Was to compare the frequency and quantity of MPRL measured by a first and ...