Searchable abstracts of presentations at key conferences in endocrinology

ea0029p236 | Calcium & Vitamin D metabolism | ICEECE2012

Bone biomarkers, body composition and metabolic profile in patients with primary hyperparathyroidism

Cvijovic G. , Micic D. , Kendereski A. , Zoric S. , Sumarac-Dumanovic M. , Stamenkovic-Pejkovic D. , Jeremic D.

Objective: Primary hyperparathyroidism (PHPT) is systemic disease affecting bone metabolism and glucose homeostasis. Patients with PHPT are insulin resistant and have atherogenic dyslipidaemia. Osteocalcin (OC) is bone biomarker associated with increased insulin secretion and insulin sensitivity and decreased visceral fat The aim of our study was to evaluate the body composition and levels of bone biomarkers (osteocalcin and betaCTx), insulin sensitivity and lipids in patients...

ea0029p436 | Clinical case reports - Thyroid/Others | ICEECE2012

Hypoparathyroidism - a rare cause of heart failure

Zoric S. , Micic D. , Kendereski A. , Cvijovic G. , Sumarac-Dumanovic M. , Stamenkovic-Pejkovic D. , Jeremic D.

Introduction: Calcium plays a key role in myocardial contractions and relaxation. Heart failure induced by hypocalcemia is rare but potentially reversible case.Case report: We present the case of 50 years old woman with muscle cramps, cataract, chest pain and dyspnea that lasts 2 years. In regional health center she was treated as psychiatric patient and COPD. Last few months she became extremely malaise with crural edemas and walking distance of 100 m. ...

ea0006p29 | Diabetes, metabolism and cardiovascular | SFE2003

THE EFECTS OF ACUTE HYPERINSULINEMIA AND INSULIN SENISTIVITY ON PLASMA HOMOCYSTEINE IN NON-OBESE WOMEN WITH POLYCYSTIC OVARY SYNDROME

Sumarac-Dumanovic M , Micic D , Mirkovic D , #Dj|#Macut|# , Kendereski A , Zoric S , Cvijovic G , Pejkovic D

Insulin resistance and/or hyperinsulinemia are risk factors for CVD. Plasma homocysteine is also important risk factor for the development of premature cardiovascular disease (CVD) in type 2 diabetes. The relationship between level of insulin and homocysteine in insulin resistant state is not clear. The aim of our study was to investigate whether plasma homocystein levels are changed by acute hyperinsulinemia and to associate the change of plasma homocysteine with the level of...

ea0029p183 | Bone & Osteoporosis | ICEECE2012

Adiponectin and bone mineral density in obese postmenopausal women

Milin J. , Micic D. , Stamenkovic-Pejkovic D. , Jeremic D. , Kendereski A. , Zoric S. , Cvijovic G. , Sumarac-Dumanovic M.

Introduction: Adiponectin and its receptors are expressed in human osteoblasts, suggesting that adiponectin may be a hormone linking bone and fat metabolism. In contrast to adiponectin anabolic effect on bone in vitro studies, clinical and animal studies suggest that adiponectin may have negative effects on bone by stimulating the receptor activator of nuclear factor-κB ligand (RANKL) pathway and inhibiting the production of the decoy receptor for RANKL and osteopr...

ea0029p1248 | Obesity | ICEECE2012

Association between osteocalcin and insulin resistance in obese women

Sumarac-Dumanovic M. , Milin J. , Stamenkovic-Pejkovic D. , Jeremic D. , Cvijovic G. , Zoric S. , Jorga J. , Micic D.

Introduction: Recent animal’s studies suggest that osteocalcin have influence on beta cell proliferation, insulin secretion and insulin sensitivity. Osteoblasts appear to regulate energy expenditure by acting on adipocytes and pancreatic islet cells via osteocalcin, a 49-residue polypeptide. In turn, adipose tissue may also influence bone remodeling by regulating the activity of osteoblasts through adipokines, including leptin and adiponectin. Some of the complex mechanis...