Searchable abstracts of presentations at key conferences in endocrinology

ea0065oc6.5 | Reproductive Endocrinology and Biology | SFEBES2019

Placental expression of estrogen related receptor γ (ERRγ) is hypoxia-sensitive and is altered in pregnancies complicated by fetal growth restriction

Zou Zhiyong , Heazell Alexander , Harris Lynda , Forbes Karen

Fetal growth restriction (FGR) defines a fetus which does not achieve its intrauterine growth potential. FGR is linked to placental dysfunction and hypoxia and is associated with a high risk of stillbirth, neonatal death and long-term complications; there are no treatments. Estrogen related receptor γ (ERRγ) is a nuclear receptor that is regulated by hypoxia in other systems; it is expressed in the placenta, thus we propose that it may be an important regulator of hy...

ea0094op2.3 | Metabolism, Obesity and Diabetes | SFEBES2023

Vitamin B12 deficiency alters leptin DNA methylation and lipid metabolism in the human placenta

Abha Abha , Zou Zhiyong , Christian Mark , Heazell Alexander E.P. , Saravanan Ponnusamy , Adaikalakoteswari Antonysunil

Background: Maternal B12 deficiency is linked with adverse metabolic disorders in infants. B12 has a potential epigenetic role which could influence placental dysfunction and fetal metabolism. Adipokines such as leptin and adiponectin play a major role in placental development by regulating lipid metabolism. Alterations in in-utero programming develop risk to obesity and metabolic diseases in offspring. B12 deficiency in mothers has been linked with higher cor...

ea0094p212 | Metabolism, Obesity and Diabetes | SFEBES2023

Insufficiency of vitamin B12 affects m6A methylation of mRNA and their related gene expression in human placenta

Madhavrao Shirgadwar Shubhendu , Zou Zhiyong , Abha Abha , Christian Mark , E.P. Heazell Alexander , Saravanan Ponnusamy , Adaikalakoteswari Antonysunil

Background: Vitamin B12 is crucial for placental development and fetal growth. B12 deficiency is associated with maternal obesity and adverse pregnancy outcomes. B12 is essential for the synthesis of S-Adenosyl methionine (SAM) which serves as a methyl donor in various cellular processes including DNA and RNA methylation. Pregnant women with low B12 have higher triglycerides, lower HDL and lower DNA methylation of cholesterol transcription factor. However, the...