Searchable abstracts of presentations at key conferences in endocrinology

ea0070ep35 | Adrenal and Cardiovascular Endocrinology | ECE2020

Mediastinal malgnant paraganglioma: An atypical presentation

Pinheiro Sara , Damasio Ines , Nunes da Silva Tiago , Leite Valeriano

Introduction: Mediastinal paragangliomas are rare. These tumours can be associated with increased morbidity and mortality when invasive growth to the heart, great vessels, esophagus and trachea occurs. Surgical resection, if feasible, is the treatment of choice.Case report: A 50-year-old man presented with severe and refractory left gluteal pain radiating to the posterior thigh for two months. The patient had no relevant medical history and no other symp...

ea0084ps1-03-27 | Thyroid Cancer CLINICAL 1 | ETA2022

Clinical significance and prognosis of solid / trabecular component areas of papillary thyroid carcinoma

Pinheiro Sara , Damasio Ines , Simoes-Pereira Joana , Nunes da Silva Tiago , Leite Valeriano

Introduction: the presence of areas with a solid / trabecular growth pattern in differentiated papillary thyroid carcinoma (PTC) represents a source of controversy regarding clinical and prognostic significance and usually requires a more aggressive therapeutic approach. The aim of this study was to compare clinicopathological characteristics, treatments and prognosis of PTC with and without solid component (SC). We also aimed to evaluate whether SC affects patient outcome in ...

ea0049ep226 | Bone & Osteoporosis | ECE2017

Cinacalcet for control of primary hyperparathyroidism: a single centre experience

da Silva Tiago Nunes , Ferreira Ana Goncalves , Cordeiro Maria Carlos , Matos Ana Catarina , Portugal Jorge

Although primary hyperparathyroidism (PHPT) is usually cured by surgery, some individuals are unable to undergo parathyroidectomy and are refractory to standard calcium lowering medical therapy. In such cases, targeted therapy with cinacalcet may be useful.The aim of this study was to access the short-term efficacy of cinacalcet in lowering calcium (Ca2+) levels in patients with PHPT unable to undergo parathyroidectomy and refractory to standa...

ea0075a08 | Adrenal gland | EYES2021

Ectopic cushing’s syndrome secondary to acinic cell carcinoma of the parotida gland: A case-report

Pinheiro Sara , Filipe Juliana , Meireles Pedro , Castelo Branco Sara , Rito Miguel , Nunes da Silva Tiago

Background: Ectopic ACTH secretion from metastatic acinic cell carcinoma (ACC) of the parotid gland is extremely rare. ACC is an uncommon, typically indolent, salivary gland neoplasm. Herein, we report a case of a high-grade ACC later diagnosed with CushingÂ’s syndrome (CS).Case presentation: A 60-year-old man presented with a laterocervical mass. Computed tomography (CT) documented a 39×38 mm mass on the parotid gland and homolateral cervical l...

ea0084op-03-16 | Oral Session 3: Advanced Thyroid Cancer | ETA2022

A clinical and molecular study of a real-world cohort of braf v600e anaplastic thyroid carcinoma treated with dabrafenib and trametinib

Nunes da Silva Tiago , Rodrigues Ricardo , Rito Miguel , Saramago Ana , Pires Carolina , Horta Mariana , Leite Valeriano , Cavaco Branca

Introduction and objectives: Anaplastic thyroid cancer (ATC) has a very low overall survival (OS) and progression free survival (PFS) due to fast growth and resistance to non-target therapies. A recent phase II study showed a dramatic increase in OS and PFS of BRAF V600E mutated ATC patients treated with Dabrafenib and Trametinib (DT). However as commonly reported in melanoma durable responses in ATC may be compromised by resistance mechanisms. Until now only a few ca...

ea0049ep486 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Insulin autoimmune syndrome: the relationship between insulin, c-peptide and glucose in active and recovering disease states

da Silva Tiago Nunes , Ferreira Ana Goncalves , Manita Isabel , Matos Ana Catarina , Carvalho Isabel , Font Paula , Prazeres Susana , Portugal Jorge

Insulin autoimmune syndrome (IAS) is a very rare cause of hypoglycaemia in western countries. One proposed mechanism is anti-insulin antibody capture of prandial insulin followed by the dissociation of insulin from anti-insulin antibody. The first objective was to study the relationship between glucose, insulin and C-peptide during a prolonged glucose load in two patients with active IAS. The second was to study the variation of these parameters between the active and the reco...

ea0037ep939 | Thyroid (non-cancer) | ECE2015

Seasonality in paediatric Graves' disease compared to the general population: impact of month of birth: a national study

da Silva Tiago Nunes , Pereira Bernardo Dias , Luiz Henrique Vara , Matos Ana Catarina , Cordeiro Maria Carlos , Raimundo Luisa , Portugal Jorge

Paediatric GravesÂ’ disease (PGD) is an uncommon autoimmune disorder with a multifactorial origin. Although, in some autoimmune endocrinophaties the seasonality of month of birth (MOB) distribution differed from the general population, this association has not been study in PGD. The aim of this work was to analyse the impact of seasonality of MOB on PGD incidence in Portugal.In 2013, the Portuguese Paediatric Society of Diabetes and Endocrinology und...

ea0035p247 | Clinical case reports Pituitary/Adrenal | ECE2014

Spindle cell oncocytoma: a new presentation of a rare disease

da Silva Tiago Nunes , Pereira Bernardo Dias , Luiz Henrique Vara , Veloza Andreia , Matos Ana Catarina , Portugal Jorge

Spindle cell oncocytoma (SCO) is a rare entity with just 18 cases reported in the literature. It was first described in 2002 and was codified as a separate diagnostic entity in the 2007 WHO classification of brain tumours. SCO is a nonadenomatous sellar neoplasm with rich vascularization and intra and supra-sellar infiltration. Usual clinical presentation consists of headache, visual field defects and pan-hypopituitarism. The preoperative diagnosis is difficult due to a lack o...

ea0084ps3-14-132 | Thyroid Cancer CLINICAL 2 | ETA2022

Efficacy and safety of lenvatinib in a cohort of well-differentiated advanced thyroid carcinomas

Damasio Ines , Maciel Joana , Figueiredo Ana , Simoes Helder , Nunes da Silva Tiago , Simoes-Pereira Joana , Horta Mariana , Santos Rita , Donato Sara , Leite Valeriano

Introduction: Treatment of differentiated thyroid carcinoma (DTC) remains a challenge in the setting of locally advanced or metastatic disease refractory to radiodine (RAI) therapy. SELECT trial demonstrated that Lenvatinib improved progression free survival (PFS) comparing to placebo.Objective: Our aim is to report the efficacy and safety of lenvatinib in our population with aggressive DTC.Methods: We retrospectively reviewed the ...

ea0041ep31 | Adrenal cortex (to include Cushing's) | ECE2016

Primary aldosteronism – results from the first Portuguese multicentre study

Nunes da Silva Tiago , Fernandes Vera , Martins Diana , Goncalves Diana , Almeida Raquel , Margarida Monteiro Ana , Neves Carolina , Simoes Helder , Marques Pedro , Alves Filipa , Pereira Maria

Primary Aldosteronism (PA) is the most prevalent cause of secondary hypertension. The aim of this work was to characterize the diagnostic workup, treatment and follow-up of confirmed PA.The adrenal tumour study group of the Portuguese Society of Endocrinology undertook the first retrospective multicentre study of Portuguese PA patients. Data was gathered from nine Portuguese Endocrinology centres (three in the north, one in the centre and five in the sou...