Searchable abstracts of presentations at key conferences in endocrinology

ea0042oc15 | (1) | Androgens2016

In vivo imaging reveals prostate pathology in the PTEN knockout murine model of prostate cancer

Bhatti Alysha , de Almeida Gilberto Serrano , Ghelfi Serena Tommasini , Dart Alwyn , Varela-Carver Anabel , Bevan Charlotte L.

Prostate cancer (PCa) is driven by the androgen receptor (AR) signalling axis and begins with prostatic intraepithelial neoplasia (PIN), progressing to invasive adenocarcinoma and eventually metastatic disease. It is treated with androgen deprivation therapies, to which, in late-stage disease, tumours often become resistant and proliferation occurs in a low androgen environment. Mutation of the PTEN tumour suppressor gene is found in approximately 30% of primary human prostate...