Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1752 | Thyroid cancer | ICEECE2012

cAMP analogs as potential therapeutic agents for poorly differentiated thyroid cancer

Grassi E , Dicitore A , Borghi M , de Filippis T , Vitale G , Persani L

Thyroid cancer is the most common endocrine malignancy characterized by a good prognosis. However, the subgroup of poorly differentiated thyroid carcinomas (PDTCs) includes neoplasia highly aggressive and scarcely responsive to currently available therapies.Site-selective cAMP analogs are able to inhibit the growth of poorly differentiated solid tumors and may represent valuable candidates for the therapy of PDTCs.We evaluated the ...

ea0029p1756 | Thyroid cancer | ICEECE2012

Role of cAMP analogs in the therapy of medullary thyroid cancer

Dicitore A , Grassi E , Borghi M , de Filippis T , Hofland L , Persani L , Vitale G

Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor highly resistant to chemo-and radiotherapy. Since several reports showed that cAMP has an antiproliferative effect on different types of solid tumors both in vitro and in vivo, we evaluated the potential anti-neoplastic activity of cAMP analogues (8-Cl-cAMP and the equimolar combination of 8-PIP-cAMP and 8-HA-cAMP) in two MTC cell lines (TT and MZ-CRC-1 that harbor C634W and M918T RET mutations, respecti...

ea0011oc61 | ThyroidOC57 British Thyroid Association Award | ECE2006

Phosphodiesterase-resistant PKA I agonists inhibit thyroid cancer cell growth

Lucchi S , Calebiro D , de Filippis T , Porazzi P , Beck-Peccoz P , Persani L

In thyroid cells TSH/cAMP stimulation is associated with proliferation and differentiation. The principal effector of cAMP is the protein kinase A (PKA) and events downstream PKA activation, signaling specificity and expression of PKA isoforms are largely unexplored. PKA is composed of two regulatory and two catalytic subunits. Two major isoforms of PKA (I and II) are determined by their specific regulatory subunits (RIα, RIβ, RIIα and RIIβ). A recent gene ...

ea0011p887 | Thyroid | ECE2006

PKA II mediates cAMP-dependent phosphorylation of CREB and activation of gene transcription in differentiated rat thyroid cells

Calebiro D , de Filippis T , Lucchi S , Porrazzi P , Beck-Peccoz P , Persani L

Thyroid stimulating hormone (TSH) is the key modulator of thyroid cell function. Binding of TSH to its receptor (TSHR) results in an increase of cAMP intracellular concentration, which activates protein kinase A (PKA) to phosphorylate CREB and other substrates. Eventually, this leads to gene transcription modification associated with both proliferation and differentiation. Two major types of PKA (PKA I and II) exist in mammal cells, but their specific role in TSH signaling is ...