Searchable abstracts of presentations at key conferences in endocrinology

ea0037gp.11.08 | Calcium, Vitamin D and Bone (1) | ECE2015

Associations of visceral and hepatic fat with serum 25-hydroxyvitamin D concentrations

de Jongh Renate , de Mutsert Renee , Lips Paul , Rosendaal Frits , den Heijer Martin

Introduction: Obesity is associated with lower serum 25-hydroxyvitamin D (25(OH)D) concentrations. A major explanatory hypothesis is that vitamin D is sequestered by adipose tissue. Another hypothesis is a decreased hepatic activation by 25-hydroxylase in obese individuals. Because adipose tissue has different characteristics and functions in different parts of the body an important question is whether serum 25(OH)D is more strongly related to visceral (VAT), hepatic, or total...

ea0081rc1.5 | Rapid Communications 1: Diabetes, Obesity, Metabolism and Nutrition 1 | ECE2022

Sex steroids regulate liver fat content and body fat distribution in both men and women: a study in transgender persons

Tebbens Marieke , Schutte Moya , Troelstra Marian , Bruinstroop Eveline , de Mutsert Renee , Nederveen Aart , den Heijer Martin , Bisschop Peter H.

Objective: Visceral adipose tissue (VAT) and liver fat content are associated with insulin resistance and cardiovascular disease and show clear sex differences. Our objective is to determine the effect of estradiol and testosterone on VAT and liver fat content in trans women (assigned male at birth, identify as female) and trans men (assigned female at birth, identify as male).Design: Open-label partly randomized intervention study in 8 trans women and 1...

ea0056oc6.5 | Genetic and environmental determinants of obesity and insulin resistance | ECE2018

Associations of different body fat deposits with serum 25-hydroxyvitamin D concentrations

Rafiq Rachida , Walschot Floor , Lips Paul , Lamb Hildo , de Roos Albert , Rosendaal Frits , den Heijer Martin , de Jongh Renate , de Mutsert Renee

Introduction: Overall and abdominal obesity are both well-established risk factors of vitamin D deficiency. However, it is unclear which fat depot is most strongly related to serum 25-hydroxyvitamin D (25(OH)D) concentrations.Objective: This study aims to distinguish specific contributions of total body fat, abdominal subcutaneous adipose tissue (aSAT), visceral adipose tissue (VAT) and hepatic fat on 25(OH)D concentrations.Methods...

ea0056gp222 | Reproduction | ECE2018

Change in visceral fat and its relation with change in lipids in trans persons during hormonal therapy: results from a multicenter prospective study

Klaver Maartje , Wiepjes Chantal , de Blok Christel , Nota Nienke , Defreyne Justine , Schneider Thomas , Fisher Alessandra , T'Sjoen Guy , den Heijer Martin , de Mutsert Renee

Introduction: Excess visceral adipose tissue (VAT) is strongly related to multiple cardiovascular risk factors such as dyslipidemia. Hormonal therapy (HT) in trans persons affects total body fat and body fat distribution, but the effect on VAT and its relation to changes in lipids is unknown. The aim of our study was to investigate the effect of one year HT on changes in VAT and its relation with changes in total cholesterol, HDL, LDL, and triglycerides after one year of HT.</...